FIG 8.
Complex domain arrangement and mechanism of the ChpA autokinase. (A) Domain arrangements of ChpA and CheA1. Hpt, Histidine-containing phosphotransfer domain; Tpt, Threonine-containing phosphotransfer domain; Spt, Serine-containing phosphotransfer domain; REC, response regulator receiver domain. (Based on data from references 17 and 141.) (B) The proposed mechanism of phosphoryl group flow in the Chp pathway. Black arrows represent findings based on biochemical and genetic data; green arrows indicate findings based on genetics only. (Based on data from reference 141.)