TABLE 2.
Transcriptional regulation of chemoreceptor and pathways genes in P. aeruginosa by different regulatory systems
| Gene cluster/ORF | Fold change(s)a |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transcriptional regulators (reference) |
Two-component systems (reference) |
Sigma factors (reference[s]) |
|||||||
| WT/ΔampRb (182) | ΔbswR/WTc (183) | ΔfleQ/WTd (156) | ΔpilR/WTe (181) | ΔfleR/WTf (156) | ΔfliA/WT (156, 184) | ΔrpoS/WT (184, 185) | ΔrpoN/WT (156, 184) | ΔsigX/WT (184) | |
| Gene cluster I (F6)g | –2.3/–3.0* | 3.0/4.2* | –2.3/–2.9* | ||||||
| Gene cluster II (F7)g | –5.2/–73.9* | –5.5/–28.4*† | –2.5/–2.8* | ||||||
| Gene cluster III (Wsp)g | –1.8/–3.3*† | –2.4/–2.7* | |||||||
| Gene cluster IV (Chp)g | –1.9/–2.4* | –2.7/–2.8* | |||||||
| Gene cluster V (F6) | –2.7 | –2.3/–3.3* | –3.1 | –2.5 | |||||
| PA0176 (McpB) | –5.2 | –8.8/–15.6† | |||||||
| PA0180 (McpA) | –5.5/–8.6† | ||||||||
| PA0411 (PilJ) | –2.7 | ||||||||
| PA1251 | 2.3 | 28.7 | |||||||
| PA1423 (BdlA) | –6.5 | –55.1 | |||||||
| PA1561 (Aer) | –2.8 | –2.9 | –8.8 | –4.4 | |||||
| PA1608 | –2.3 | –14.2 | –3.3 | ||||||
| PA1646 | 2.0 | –4.2 | 5.4 | ||||||
| PA1930 (McpS) | 3.9 | –16.3/–20.5† | –8.6 | ||||||
| PA2561 (CtpH) | –2.0 | –4.2 | |||||||
| PA2573 | –8.4/–12.1† | ||||||||
| PA2652 (CtpM) | –2.7 | –2.3 | –10.7 | ||||||
| PA2654 (TlpQ) | –4.3 | –3.7 | –57.9 | ||||||
| PA2788 (McpN) | –12.4 | –6.8 | –21.3 | ||||||
| PA2867 | –3.4 | –4.1 | –3.4 | –5.7 | –14.4 | –2.1 | |||
| PA2920 | –2.6 | ||||||||
| PA3708 (WspA) | –2.3 | –2.3 | |||||||
| PA4290 | 3.0 | ||||||||
| PA4307 (PctC) | –12.0 | –4.2 | –6.8/–15.0† | –6.5 | –4.5 | ||||
| PA4309 (PctA) | –2.1 | –2.6 | –8.4 | –20.5 | |||||
| PA4310 (PctB) | –80.6 | –3.2 | –32.5 | –21.1/–83.7† | –45.7 | –3.9 | |||
| PA4520 | –2.8 | –4.0 | |||||||
| PA4633 | –2.9 | –4.5/–6.0† | –11.8 | ||||||
| PA4844 (CtpL) | |||||||||
| PA4915 | –12.7 | –6.6/–11.0† | |||||||
| PA5072 (McpK) | –5.9 | ||||||||
a
*, Both the lowest and the highest fold changes among the differentially expressed genes per cluster are listed; †, values for two different studies are listed. WT, wild type.
b
Signal: cell wall muropeptides (179).
c
Signal: unknown.
e
Signal: PilA (181). Current data support that PilA acts as an intramembrane inhibitory signal through its interactions with the sensor kinase PilS.
f
Signal: unknown.
g
At least two genes per gene cluster have to be altered for listing.