TABLE 3.

Transcriptional regulation of chemoreceptor and pathways genes in P. aeruginosa by different signal molecules

Gene cluster/ORF	Fold change(s)
	Signal molecules and second messengers (reference[s])				Quorum-sensing signaling (reference)
	Pi	c-di-GMP	cAMP	ppGpp	Acyl-homoserine lactones
	WT (0.2 mM Pi)/ WT (1 mM Pi) (43)	ΔwspF pelA pslBCDa/ ΔpelA pslBCD ΔwspFa/WT (8, 111)	ΔcyaABb/WT (186)	ΔrelA ΔspoTc/WT (158)	WT/ΔlasR ΔrhlR (187)	ΔlasI ΔrhlI + AHLd/ ΔlasI ΔrhlI (188)
Gene cluster I (F6)e				1.6/2.2f
Gene cluster II (F7)e	4.0/15.4f			1.5/2.7f	3.7/4.6f	1.9g
Gene cluster III (Wsp)e
Gene cluster IV (Chp)e		–1.6/–1.9f	–2.6/–4.6f	1.6/3.3f		1.5/1.7f
Gene cluster V (F6)				2.4/2.8f
PA0176 (McpB)	15.4				3.9
PA0180 (McpA)
PA0411 (PilJ)			3.1	3.3		1.5
PA1251
PA1423 (BdlA)	2.7	2.1		5.2
PA1561 (Aer)	2.2	2.7
PA1608			2.0	4.2		2.2
PA1646				4.7
PA1930 (McpS)	3.0			3.9	3.8
PA2561 (CtpH)	2.8
PA2573	5.0				3.9	2.7
PA2652 (CtpM)			2.1
PA2654 (TlpQ)		2.4		2.8
PA2788 (McpN)	2.2
PA2867		2.5	2.3			1.6
PA2920	2.2			3.7
PA3708 (WspA)
PA4290	3.0
PA4307 (PctC)		6.2/7.2h	3.5			2.4
PA4309 (PctA)		2.1				1.6
PA4310 (PctB)		1.7
PA4520				2.6		2.1
PA4633		2.3		3.5
PA4844 (CtpL)	7.1
PA4915	2.1			2.2
PA5072 (McpK)		2.2

^aIncreased c-di-GMP levels.

^bReduced cAMP levels.

^cppGpp-deficient mutant.

^d1 μM 3OC12-HSL and 2 μM C4-HSL were added.

^eAt least two genes per gene cluster have to be altered for listing.

^fThe lowest and highest fold changes among differentially expressed genes per cluster are listed.

^gA single fold change value was given for the entire F7 gene cluster.

^hValues for two different studies are listed.