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. 2021 Jan;31(1):101–109. doi: 10.1101/gr.267047.120

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© 2021 Uzun et al.; Published by Cold Spring Harbor Laboratory Press

This article, published in Genome Research, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.

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Figure 3. — Predicted gene activity using methylome data improves cell subtype identification for neurons. (A) UMAP of clustering result generated using mean promoter demethylation (MPD) as the input. (B) Violin plot of MPD values for marker genes for excitatory (Tyro3, Slc17a7, Tbr1, Itpka) and inhibitory (Slc6a1, Erbb4) neurons. (C) Same as A but using predicted gene activity (PGA) as the input. (D) Same as B but using predicted gene activity as the input.