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. 2021 Jan;31(1):110–120. doi: 10.1101/gr.256636.119

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© 2021 Zhen et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 1. — The ancestral and outgroup population sizes greatly influence α. (A) Schematic demographic models illustrate the Simple and Complex models with associated parameters. In the Simple model, the size of the ancestral population (Nanc) and the size of the outgroup (Nout) are assumed to be the same as the ancestral size of the ingroup (Nanc.in). This assumption is relaxed in the Complex model. (B) Effect of Nanc and Nout on estimates of α for humans using the chimpanzee as an outgroup. Colors denote different values of Nanc. Arrow points to the estimate of α from the Simple model, where Nanc = Nout = Nanc.in = 7067.