FIG 1.

Expression levels of GLUT SLC2 species in normal tissues and breast tumors. (A) The expression level of each of the 14 Slc2 family members is shown as a heat map of RNA-Seq reads (transcripts per kilobase million [TPM]) in each of the human tissues indicated (data summarized from GTEx Portal, v8). (B) The GLUT family dendrogram, redrawn from reference 2, shows three subclasses of GLUT proteins (class I, II, and III). GLUT14 is not indicated on this scheme as it has now been identified as a paralog of GLUT3 and is therefore grouped with class I SLC2 species. GLUT13 is more typically called HMIT (H⁺-myo-inositol symporter). (C) Expression of SLC2 mRNA species is described from the RNA-Seq database of The Cancer Genome Atlas for breast tumors (1,091 total) (24) and for near-adjacent, nontumor breast samples (labeled Normal; n = 111).