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. 2021 Feb;31(2):327–336. doi: 10.1101/gr.263202.120

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© 2021 Neville et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 4. — Meta-analysis of heritability partitioned across 27 UK Biobank traits for nORF regions. Heritability enrichment was compared for canonical gene annotation from GENCODE versus nORF annotation for (A) common variation enrichment (CVE), defined as the proportion of common variant heritability explained by the annotation divided by the proportion of common variants in the annotation; (B) low-frequency variant enrichment (LFVE), defined similarly to CVE; and (C) the LFVE/CVE ratio. Higher enrichments suggest more functional importance in the studied traits and diseases.