Table 2.

Resource use and average days of incapacity to work for the different diseases, health conditions and treatments.

Disease or health condition	Resource use	Average days of incapacity to work
Hyperthyroidism in the year of diagnosis (without thyroidectomy/RAI) (35, 47)	1. Doctor’s appointment (1st)– Full-body consultation– ECG2. Doctor’s appointment (2nd) – Thyroid sonography – Blood sampling, laboratory tests3. Doctor’s appointment (3rd) – Consultation, discussion of results4. Doctor’s appointment (3-month follow-up) – Consultation, examination – Blood sampling, laboratory tests5. Doctor’s appointment (6- to 12-month follow-up) – Consultation, examination – Thyroid sonography – Blood sampling, laboratory tests6. Medication – Anti-thyroid medication for 9 months	18.17
Euthyroid health condition with ATM (individuals one year after diagnosis of hyperthyroidism) (35, 47)	1. Doctor’s appointment (follow-up) (one per year) – Consultation, examination – Thyroid sonography – Blood sampling, laboratory tests2. Medication – Hormone replacement therapy for 12 months	0
Hypothyroidism in the year of diagnosis (25, 35)	1. Doctor’s appointment (1st) – Full-body consultation – ECG2. Doctor’s appointment (2nd) – Thyroid sonography – Blood sampling, laboratory tests3. Doctor’s appointment (3rd) – Consultation, discussion of results4. Doctor’s appointment (3-month follow-up) – Consultation, examination – Blood sampling, laboratory tests5. Doctor’s appointment (6 –12 month follow-up) – Consultation, examination – Thyroid sonography – Blood sampling, laboratory tests6. Medication – Hormone replacement therapy for 9 months	17.11
Euthyroid health condition with HRT (individuals one year after diagnosis of hypothyroidism) (25, 35)	1. Doctor’s appointment (follow-up) (one per year) – Consultation, examination – Thyroid sonography – Blood sampling, laboratory tests2. Medication – Hormone replacement therapy for 12 months	0
Goiter/thyroid nodules (without thyroidectomy/RAI) (18, 19, 22, 48)	1. Doctor’s appointment (1st) – Full-body consultation – ECG2. Doctor’s appointment (2nd) – Thyroid sonography – Blood sampling, laboratory tests3. Doctor’s appointment (3rd) – Consultation, discussion of results4. Doctor’s appointment (3-month follow-up) – Consultation, examination – Blood sampling, laboratory tests5. Doctor’s appointment (6 –12 month follow-up) – Consultation, examination – Thyroid sonography – Blood sampling, laboratory tests6. Optional: scintigraphy and fine-needle biopsy	17.51
Spontaneous abortion (43, 44)	Option 1: Expectant care – Noninvasive assistance – Consultation of female genitalia – SonographyOption 2: Medical care – Noninvasive assistance – Sonography – Medication Option 3: Surgical care: First consultation – Noninvasive assistance – Consultation of female genitalia – SonographyOption 3: Surgical care: Surgery (OPS-Code 5-751) – Average period of hospitalization: 3 daysOption 3: Surgical care: Second consultation	9.31
Thyroidectomy (41)	Weighted mean of costs for different types of thyroidectomies OPS-Codes: 5-060: Incision in the area of the thyroid gland (2.7%) 5-061: Hemithyreoidectomy (28.2%) 5-062: Other partial thyroid gland resection (18.6%) 5-063: Thyroidectomy (50.2%) 5-064: Thyroid surgery via sternotomy (0.3%)	-
Radioiodine therapy (42)	Weighted mean of costs for different types of radioiodine therapies OPS-Codes: Radioiodine therapy up to 1,2 GBq I-131 8-531.00: without rh-TSH (64.6%) 8-531.01: with rh-TSH (4.3%) Radioiodine therapy from 1,2 to 5 GBq I-131 8-531.10: without rh-TSH (19.7%) 8-531.1: with rh-TSH (6.1%) Radioiodine therapy with 5 or more GBq I-131 8-531.20: without rh-TSH (3%) 8-531.21: with rh-TSH (2.3%)	-

ATM, anti-thyroid medication; GBq, gigabecquerel; HRT, hormone replacement therapy; I-131, radioisotope of iodine; IDD, iodine deficiency disorders; OPS, ‘German surgery and procedure code’ (Operations- und Prozedurenschlüssel); RAI, radioiodine therapy; rh-TSH, recombinant thyrotropin.