Table 1.

Example schematic for a cost calculation: hyperthyroidism in the year of diagnosis.

Uniform Value Scale (89.7% of population) (31)			Statutes of medical fees (10.3% of population) (32)
Resource use		Costs in Euro 2018	Resource use	Costs in Euro 2018
1st doctor’s visit
One-time flat rate per insured person		24.14	Consultation	10.72
Full-body examination		12.04	Full-body examination	34.86
ECG		8.52	ECG	15.95
2nd doctor’s visit
Consultation flat rate		1.92	Symptom-related examination	10.72
Sonography of the thyroid		9.06	Sonography of the thyroid	26.81
			Blood sampling	4.19
Laboratory		13.15	Laboratory	79.6
3rd doctor’s visit
Consultation flat rate		1.92	Symptom-related examination	10.72
			Discussion of results	17.43
Follow-up visit after 3 months
Consultation flat rate		1.92	Symptom-related examination	10.72
Sonography of the thyroid		9.06	Sonography of the thyroid	26.81
			Blood sampling	4.19
Laboratory		13.15	Laboratory	79.6
Follow-up visit after 6–12 months
Consultation flat rate		1.92	Symptom-related examination	10.72
Sonography of the thyroid		9.06	Sonography of the thyroid	26.81
			Blood sampling	4.19
Laboratory		13.15	Laboratory	79.6
SUM		119.01	SUM	453.64
Weighted mean (0.897 × SUM Uniform Value Scale + 0.103 × SUM ‘Statutes of medical fees’) according to the proportion of patients insured by statutory health insurances and private health insurances (33):				153.58
Direct non-medical costs (€ 10 per visit for transportation)				50
Anti-thyroid medication		Sold defined daily dosis (DDD) in 2016 (Mio.) (28)	Proportion	Costs per DDD (Euro 2018) (36)	Additional costs for patients (37)
Thiamazol		26.1	0.58	0.17	0.05
Carbimazol		16.1	0.36	0.36	0.05
Natriumperchlorat		1.5	0.03	0.67	0.07
Propylthiouracil		1.1	0.02	0.29	0.05
Mean costs per DDD (Euro 2018) = proportion × (costs per DDD + additional costs for patients)					0.31
Costs per patient per year (Euro 2018) = 365 × mean costs per DDD					112.62
Total costs per case for hyperthyroidism in the year of diagnosis (Weighted mean Uniform Value Scale/Statutes of medical fees + direct non-medical costs + medication costs)					316.19
ICD 10-Code	Diagnosis	Absence of work in days per case year (38)	Total labor costs per daya	Estimation according to IQWIG guidelines (13) (80% of labor costs)	Monetary productivity loss per year per person with hyperthyroidism
E05	Hyperthyroidism	18.17	169.86	135.89	2469.13
Total costs per case for hyperthyroidism in the year of diagnosis including productivity loss (Weighted mean Uniform Value Scale/Statutes of medical fees + direct non-medical costs + medication costs + productivity loss)					2785.32

^aAssuming 35.6 h of work per week and labor costs of 33.40 €/h (39).

ATM, anti-thyroid medication.