Figure 1.

Loss of chromosome Y in ≥75% metaphases is associated with morphological features of myeloid neoplasia and progression to myelodysplastic syndrome. (A) Mosaic graph demonstrating pathological diagnoses in relation to percentage of metaphases involved by loss of chromosome Y (LOY) ; divided into four bins for ease of comparison. ≥75% LOY is significantly associated with myeloid neoplasia; while <25% LOY is associated with no/minimal dysplasia. (B) Failure plot demonstrating presence or absence of evidence of progression in patients with LOY with no dysplasia/minimal dysplasia at presentation. Each dot represents diagnosis of myelodysplastic syndrome during follow up. The red line represents patients with ≥75% LOY, while the blue line represents patients with <75% LOY.