Table 3.
Results Cox proportional hazard regression with the different outcome evaluations.
| Weight distribution | CBPI | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variable | Symmetry Index (p = 0.014) | Deviation (p = 0.251) | HVAS (p = 0.036) | PSS (p = 0.881) | PIS (p = 0.025) | LOAD (p = 0.006) | |||||||
| HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | ||
| Treatment | 0.001* | 0.159 | 0.005* | 0.529 | 0.001* | 0.000* | |||||||
| Control | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |||||||
| HG | 0.23 (0.08–0.65) | 0.006* | 0.25 (0.07–0.84) | 0.026* | 0.19 (0.06–0.64) | 0.007* | 0.29 (0.08–1.16) | 0.081 | 0.06 (0.15–0.26) | 0.000* | 0.06 (0.02–0.25) | 0.000* | |
| PCG | 0.24 (0.21–0.26) | 0.000* | 0.29 (0.09–0.96) | 0.042* | 0.26 (0.09–0.82) | 0.021* | 0.57 (0.19–1.73) | 0.322 | 0.12 (0.03–0.43) | 0.001* | 0.19 (0.06–0.62) | 0.005* | |
| SG | 0.21 (0.07–0.60) | 0.004* | 0.42 (0.12–1.47) | 0.176 | 0.31 (0.09–1.08) | 0.066 | 0.65 (0.19–2.18) | 0.487 | 0.09 (0.02–0.36) | 0.001* | 0.08 (0.02–0.28) | 0.000* | |
| THG | 0.29 (0.09-0.83) | 0.021* | 0.53 (0.18–1.54) | 0.245 | 0.58 (0.20–1.66) | 0.311 | 0.72 (0.23–2.25) | 0.573 | 0.08 (0.02–0.32) | 0.000* | 0.09 (0.03–0.36) | 0.001* | |
| OFA score | 0.582 | 0.608 | 0.195 | 0.998 | 0.621 | 0.211 | |||||||
| Mild | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |||||||
| Moderate | 0.70 (0.29–1.69) | 0.430 | 0.75 (0.30–1.85) | 0.528 | 1.49 (0.63–3.52) | 0.358 | 1.024 (0.41-2.57) | 0.960 | 1.53 (0.65–3.61) | 0.330 | 2.18 (0.89–5.34) | 0.088 | |
| Severe | 0.58 (0.17–1.94) | 0.378 | 1.44 (0.37–5.58) | 0.597 | 3.00 (0.88–10.29) | 0.079 | 0.99 (0.22–4.41) | 0.990 | 1.25 (0.31–5.00) | 0.749 | 1.03 (0.23–4.61) | 0.972 | |
| Breed | 0.861 | 0.293 | 0.752 | 0.856 | 0.631 | 0.073 | |||||||
| LR | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |||||||
| GSD | 0.74 (0.24–2.28) | 0.589 | 0.44 (0.13–1.54) | 0.202 | 0.52 (0.13–2.14) | 0.368 | 1.42 (0.36–5.61) | 0.619 | 0.52 (0.14–1.92) | 0.327 | 0.76 (0.21–2.76) | 0.672 | |
| BM | 0.63 (0.21–1.91) | 0.411 | 0.31 (0.09–1.13) | 0.076 | 0.47 (0.12–1.85) | 0.283 | 0.92 (0.27–3.15) | 0.888 | 0.46 (0.14–1.58) | 0.217 | 0.35 (0.09–1.33) | 0.121 | |
| DSD | 0.79 (0.22–2.86) | 0.724 | 0.58 (0.12–2.74) | 0.493 | 0.58 (0.13–2.72) | 0.493 | 1.39 (0.54–2.92) | 0.684 | 0.43 (0.10–1.82) | 0.249 | 0.17 (0.03–0.83) | 0.028* | |
| Sex | |||||||||||||
| Male | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |||||||
| Female | 1.51 (0.76–2.99) | 0.238 | 0.77 (0.34–1.75) | 0.536 | 0.33 (0.12–0.87) | 0.025* | 1.25 (0.54–2.92) | 0.607 | 0.85 (0.37–1.97) | 0.704 | 1.17 (0.49–2.79) | 0.721 | |
| Age | 0.90 (0.77–1.06) | 0.216 | 0.9 (0.75–1.09) | 0.274 | 1.09 (0.91–1.29) | 0.363 | 1.13 (0.93–1.37) | 0.222 | 0.912 (0.77–1.08) | 0.299 | 0.9 (0.76–1.07) | 0.229 | |
| COI | |||||||||||||
| Variable | Stiffness (p = 0.034) | Function (p = 0.023) | Gait (p = 0.069) | QOL (p = 0.325) | Total (p = 0.053) | ||||||||
| HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | ||||
| Treatment | 0.099 | 0.022* | 0.056 | 0.840 | 0.163 | ||||||||
| Control | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | ||||||||
| HG | 0.19 (0.05–0.74) | 0.016* | 0.09 (0.02–0.43) | 0.002* | 0.20 (0.06–0.71) | 0.012* | 0.64 (0.19–2.09) | 0.463 | 0.29 (0.09–0.92) | 0.036* | |||
| PCG | 0.23 (0.07–0.77) | 0.018* | 0.33 (0.11–1.02) | 0.054 | 0.21 (0.07–0.67) | 0.009* | 0.57 (0.21–1.58) | 0.282 | 0.29 (0.09–0.87) | 0.030* | |||
| SG | 0.31 (0.09–1.09) | 0.069 | 0.28 (0.08–1.01) | 0.051 | 0.36 (0.11–1.15) | 0.083 | 0.87 (0.28–0.67) | 0.807 | 0.54 (0.17–1.66) | 0.279 | |||
| THG | 0.31 (0.09–1.09) | 0.069 | 0.33 (0.11–1.02) | 0.054 | 0.29 (0.09–0.92) | 0.036* | 0.65 (0.22–1.96) | 0.444 | 0.49 (0.17–1.41) | 0.188 | |||
| OFA score | 0.223 | 0.068 | 0.439 | 0.303 | 0.041* | ||||||||
| Mild | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | ||||||||
| Moderate | 1.05 (0.39–2.84) | 0.918 | 0.89 (0.34–2.36) | 0.823 | 0.63 (0.24–1.64) | 0.344 | 0.48 (0.19–1.22) | 0.123 | 0.69 (0.28–1.73) | 0.431 | |||
| Severe | 3.11 (0.79–12.13) | 0.102 | 5.09 (1.18–21.98) | 0.029* | 1.34 (0.39–4.629 | 0.641 | 0.78 (0.22–2.77) | 0.696 | 4.19 (1.08–16.24) | 0.038* | |||
| Breed | 0.069 | 0.559 | 0.255 | 0.320 | 0.997 | ||||||||
| LR | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | ||||||||
| GSD | 0.46 (0.10–2.00) | 0.298 | 2.54 (0.56–11.47) | 0.226 | 0.71 (0.18–2.78) | 0.622 | 2.31 (0.65–8.25) | 0.199 | 0.92 (0.26–3.28) | 0.898 | |||
| BM | 1.39 (0.40–4.81) | 0.606 | 2.04 (0.52–7.99) | 0.309 | 1.15 (0.33−3.96) | 0.824 | 0.87 (0.33–7.49) | 0.814 | 0.92 (0.29–2.93) | 0.893 | |||
| DSD | 0.22 (0.03–1.51) | 0.124 | 1.18 (0.22–6.22) | 0.845 | 0.29 (0.05–1.58) | 0.153 | 1.57 (0.33–7.49) | 0.572 | 1.00 (0.24–4.15) | 0.995 | |||
| Sex | |||||||||||||
| Male | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | ||||||||
| Female | 1.49 (0.60–3.69) | 0.386 | 1.58 (0.62–4.01) | 0.337 | 1.19 (0.52–2.74) | 0.685 | 3.16 (1.35–7.39) | 0.008* | 2.02 (0.89–4.55) | 0.089 | |||
| Age | 1.08 (0.91–1.29) | 0.378 | 1.16 (0.96–1.41) | 0.119 | 1.19 (0.99–1.43) | 0.071 | 1.06 (0.87–1.29) | 0.572 | 1.14 (0.94–1.37) | 0.180 | |||
BM, Belgian Malinois Shepherd Dog; CBPI, Canine Brief Pain Inventory; COI, Canine Orthopedic Index; DSD, Dutch Shepherd Dog; GSD, German Shepherd Dog; HG, Hylan G-F 20 group; HVAS, Hudson Visual Analog Scale; LOAD, Liverpool Osteoarthritis in Dogs; LR, Labrador Retriever; OFA, Orthopedic Foundation for Animals; PCG, Platelet Concentrate group; PIS, Pain Interference Score; PSS, Pain Severity Score; QOL, Quality of Life, SG, Stanozolol group; THG, Triamcinolone hexacetonide group.
*
indicates significance.