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. 2021 Jan 18;11:623190. doi: 10.3389/fphys.2020.623190

FIGURE 2.

FIGURE 2

Upregulated transcripts in hearts of PKP2cKO/RiboTag mice. (A) Principal component analysis (PCA) based on RNA-seq of myocyte control or PKP2cKO/RiboTag mice. The 78% of variance can be explained by treatment (PKP2 knockdown) whereas sex explained only 9% of variance, allowing data to be combined. (B) Volcano plot representing differential transcriptome of PKP2cKO/RiboTag myocytes vs control. “Upregulated” (red) or “downregulated” (blue) refers to abundance in PKP2 knocked-down myocytes (control as reference). Inclusion criteria are as follows: Log2 fold change ± 0.5 and FDR < 0.05. (C) Significantly enriched Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways from upregulated genes. (D) Significantly enriched biological process clusters from upregulated genes in PKP2cKO.