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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: J Physiol. 2020 Dec 12;599(2):571–592. doi: 10.1113/JP281011

Figure 13. The activity of Piezo1 regulates outflow facility of trabecular outflow pathway.

Figure 13.

(A) Shown are representative traces that depict flow (Q) and pressure (P) measured in perfused, enucleated and paired mouse eyes. Upper panels show flow rate as a function of time, and lower panels show corresponding pressure steps as a function of time. Traces show GsMTx4-treated (red) and untreated (blue) eyes. (B) Overlaid traces from both GsMTx4-treated and control treatments. Upper panel depicts flow as a function of pressure steps, and lower panel depicts outflow facility (C) as a function of pressure steps, where C is Q/P. The exponent β characterizes the nonlinearity of the flow-pressure relationship. Cr is the outflow facility calculated at the reference pressure of 8 mmHg. (C) GsMTx4 treatment reduced conventional, pressure-dependent outflow compared with no drug treatment (**p = 0.0047, n = 8 eyes, paired t-test). Mean ± SD. GsMTx4 was applied at a concentration 6 μM.