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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: J Physiol. 2020 Dec 12;599(2):571–592. doi: 10.1113/JP281011

Figure 4. Piezo1 mediates the indentation-evoked current with msec kinetics.

Figure 4.

(A) A representative trace of the whole-cell current induced by cell poking in TM cells. Poking is indicated by an arrow. The holding potential was −40 mV (B) The activation (τa) and inactivation (τi) time constants of poking-induced current. Time constants are represented as the mean ± SD. (C) Current density. Shown are the mean ± SD. ###p = 0.0003; two-samples t-test; n = 4 cells and n = 7 cells for control and GsMTx4 (5 μM), respectively. Gray symbols in the middle and the right plots represent individual values.