Table 1.
Demographic, comorbidity, and follow-up comparisons among the 3 CPAP-use groups.
| Response | No CPAP (n = 24) | Noncompliant (n = 30) | Compliant (n = 42) | P |
|---|---|---|---|---|
| Age at MCI, years | .804a | |||
| Mean (SD) | 70.1 (11.3) | 71.4 (7.7) | 70.0 (9.4) | |
| Range | 40–92 | 53–85 | 44–90 | |
| Median (IQR) | 70.5 (12) | 71.5 (10) | 69 (15) | |
| Sex, n (%) | .257b | |||
| Male | 13 (54) | 19 (63) | 31 (74) | |
| Female | 11 (46) | 11 (37) | 11 (26) | |
| Race, n (%) | .074c | |||
| Caucasian | 15 (63) | 15 (50) | 33 (79) | |
| African American | 6 (25) | 10 (33) | 7 (17) | |
| Other | 2 (8) | 4 (13) | 0 (0) | |
| Unknown | 1 (4) | 1 (3) | 2 (5) | |
| Education, n (%) | .527c | |||
| Less than high school | 1 (6) | 2 (10) | 2 (7) | |
| High school | 7 (41) | 7 (35) | 5 (17) | |
| Some college | 4 (24) | 3 (15) | 6 (21) | |
| College degree or more | 5 (29) | 8 (40) | 16 (55) | |
| BMI, kg/m2 | .786a | |||
| Mean (SD) | 30.1 (6.3) | 30.0 (7.2) | 29.1 (6.2) | |
| Range | 20.43–44 | 22–53 | 18.8–50 | |
| BMI category, n (%) | .940b | |||
| Normal | 5 (21) | 8 (27) | 10 (24) | |
| Overweight | 7 (29) | 10 (33) | 15 (36) | |
| Obese | 12 (50) | 12 (40) | 17 (40) | |
| Medication, n (%) | .261c | |||
| No | 22 (92) | 22 (73) | 35 (83) | |
| Yes, already taking | 1 (4) | 1 (3) | 3 (7) | |
| Yes, starting | 1 (4) | 7 (23) | 4 (10) | |
| AHI, events/h | .052d | |||
| Mean (SD) | 19.4 (14.0) | 28.0 (20.1) | 28.2 (15.0) | |
| Range | 4–61.98 | 6.01–84.88 | 5.96–64 | |
| ESS | .986d | |||
| Mean (SD) | 8.5 (5.9) | 8.2 (5.0) | 8.5 (5.6) | |
| Range | 0–20 | 0–18 | 0–20 | |
| Neurology follow-up, years | .819d | |||
| Mean (SD) | 2.7 (2.2) | 2.8 (1.9) | 2.8 (1.8) | |
| Range | 0.14–10.4 | 0.74–9.9 | 0.15–8.4 | |
| Median (IQR) | 2.9 (1.5) | 2.7 (1.5) | 2.6 (1.5) | |
| Trail A, seconds | .132d | |||
| Mean (SD) | 46.5 (15.2) | 60.1 (21.5) | 57.8 (34.4) | |
| Range | 24–78 | 27–116 | 20–157 | |
| Median (IQR) | 43.5 (13) | 58.5 (19) | 50.5 (38) | |
| Trail B,e seconds | .381d | |||
| Mean (SD) | 164.9 (104) | 193.9 (98.6) | 159.8 (92) | |
| Range | 49–300 | 62–300 | 45–300 | |
| Median (IQR) | 137 (270) | 192 (199) | 127 (188.5) | |
| CDR sum of boxes | .861d | |||
| Mean (SD) | 1.54 (0.97) | 1.4 (0.95) | 1.61 (1.77) | |
| Range | 0.5–4 | 0–4.5 | 0.5–5 | |
| Median (IQR) | 1.5 (1) | 1(1) | 1 (1.25) |
There were no statistical differences between the compliance groups in terms of baseline demographics, sleep apnea severity, ESS, or behavioral scales at time of MCI diagnosis. aAnalysis of variance. bChi-square test. cFisher's exact test. dKruskal-Wallis test. eTrail B times >300 minutes were truncated at 300 minutes. AHI = apnea-hypopnea index; BMI = body mass index; CDR = Clinical Dementia Rating; CPAP = continuous positive airway pressure; ESS = Epworth Sleepiness Scale; IQR = interquartile range; MCI = mild cognitive impairment.