Figure 2.

Rac-related GTPases RhoG and Cdc42 fail to induce lamellipodia in the absence of Rac expression

(a) Cell morphologies of Rac1/2/3 KO cells (clone #1) expressing EGFP-tagged GTPases, as indicated. (b) Quantification of lamellipodial phenotypes was performed as described for Figure 1(c). n gives number of cells analysed, data correspond to arithmetic means ± SEM from at least three independent experiments. Statistical significance was assessed for differences between percentages of cells with ‘no lamellipodia’ phenotype. ***p < 0.001 (two-sample, two-sided t-test).