Figure 1.

Cytogenetic abnormalities in high-risk clonal evolution stratified by time to evolution from initial immunosuppressive treatment for severe aplastic anemia. There were 58 high-risk clonal evolutions in this large cohort of 666 subjects with severe aplastic anemia (SAA) diagnosis treated with immunosuppressive treatment (IST). Majority occurred before 5 years and the most common cytogenetic abnormalities were in chromosome 7 including aneuploidy, partial loss/deletion, or inversion. Chr7: chromosome 7; NA: not available.