Figure 1.

Timeline of the protocol, participants take the pill 45 min before start entering bath; thereafter, participants are prepared and practice the cognitive tests. At T = −15 the experiment starts outside the bath and continues at T = 0 inside the bath. Twenty minutes after entering the bath (T = 20) the second bout of the cognitive tests takes place. Then, either after 60 min in the bath, or when gastrointestinal temperature (Tcore) reaches 38.5°C participants start with the final bout of the cognitive tests. Thereafter, the experiment is finished and participants carefully leave the bath