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Hypothesized mechanistic model for the spironolactone‐induced XPB degradation. Spironolactone induces ubiquitination of XPB within holo-TFIIH by a putative cullin-based E3 ubiquitin ligase SCFFBXL18, in manner dependent on integrity of holo-TFIIH and ATPase activity of Cdk7 in CAK complex. The ubiquitinated XPB is selectively extracted from holo-TFIIH by VCP/p97 complex and presented to proteasome for degradation
