Table 1.

Genes transcriptionally induced during the C. albicans morphological transition and involved in pathogenesis and/or virulence-related properties show significantly reduced TE

Gene namea	Ref. #	Descriptiona	Fold change in transcriptb	Fold change in TEc
TLO1	orf19.7544	Member of TLO gene family	15	−22.8
INO2	orf19.7539	Transcriptional activator of genes involved in phosphatidylcholine and phosphatidylinositol biosynthesis	3.4	−16.2
C3_05990C	orf19.7380	Protein of unknown function	17.8	−13.9
CTA2	orf19.6112	Putative transcription factor; Med2 mediator domain	15.2	−9.4
TLO34	orf19.2661	Member of TLO gene family	21.4	−7.3
ECE1	orf19.3374	Candidalysin, cytolytic peptide toxin essential for mucosal infection	388.0	−5.5
HWP1	orf19.1321	Hyphal wall protein, adhesin, host transglutaminase substrate mimic	362.0	−5.4
SKN7	orf19.971	Putative response regulator in phophorelay signal transduction; required for H2O2 resistance	3.7	−4.9
DDR48	orf19.4082	Immunogenic stress-associated protein	22.1	−4.5
HXK1	orf19.2154	GlcNAc kinase; required for hyphal growth and virulence	4.2	−4.3
RBT1	orf19.1327	cell wall protein similar to Hwp1; required for virulence	64.4	−2.7
SFU1	orf19.4869	GATA-type transcriptional regulator of iron-responsive genes; promotes gastrointestinal commensalism	2.0	−2.4
SFL2	orf19.3969	Transcriptional regulator of morphogenesis	2.0	−2.3
SLK19	orf19.6763	Alkaline-induce plasma membrane protein important for cell wall; required for virulence	2.2	−2.1

^aGene names and descriptions based on Candida Genome Database annotation (http://www.candidagenome.org).

^bIndicates mean fold change in transcript levels (n = 3, TPM >1 in at least two replicates, P_adj ≤ 0.05) in cells grown in YEPD + 10% serum at 37°C vs YEPD at 30°C at the 1-h time point.

^cIndicates mean fold change in TE (n = 3, TPM >1 in at least two replicates, P ≤ 0.05) in cells grown in YEPD + 10% serum at 37°C vs YEPD at 30°C at the 1-h time point.