Table 1.
Baseline characteristics at diagnosis for individuals with RA by haematological abnormality
| Characteristics | Overall (n = 6591) | Anaemia (n = 1066) | P-valuea | Neutropenia (n = 38) | P-valueb | Lymphopenia (n = 97) | P-valuec |
|---|---|---|---|---|---|---|---|
| Age, mean (s.d.), years | 58.7 (15.5) | 63.9 (15.6) | <0.001 | 59.8 (13.2) | 0.64 | 64.0 (15.3) | 0.001 |
| Sex, male, n (%) | 2142 (32.5) | 556 (52.2) | <0.001 | 16 (42.1) | 0.27 | 32 (33.0) | 1.00 |
| Ethnicity, n (%) | <0.001 | <0.001 | 0.542 | ||||
| White | 4883 (74.1) | 740 (69.4) | 17 (44.7) | 74 (76.3) | |||
| Asian | 255 (3.9) | 65 (6.1) | 3 (7.9) | 2 (2.1) | |||
| Black | 128 (1.9) | 26 (2.4) | 11 (28.9) | 0 (0.0) | |||
| Mixed | 26 (0.4) | 7 (0.7) | 0 (0.0) | 0 (0.0) | |||
| Other | 36 (0.5) | 4 (0.5) | 0 (0.0) | 0 (0.0) | |||
| Missing | 1263 (19.2) | 224 (21) | 7 (18.4) | 21 (21.6) | |||
| Smoking status, n (%) | <0.001 | 0.016 | 0.196 | ||||
| Never | 1853 (28.1) | 294 (27.6) | 12 (31.6) | 32 (33.0) | |||
| Current | 1348 (20.5) | 167 (15.7) | 5 (13.2) | 15 (15.5) | |||
| Former | 2968 (45.0) | 528 (49.5) | 14 (36.8) | 40 (41.2) | |||
| Missing | 422 (6.4) | 77 (7.2) | 7 (18.4) | 10 (10.3) | |||
| BMI, mean (s.d.), kg/m2d | 27.7 (6.0) | 27.2 (6.3) | 0.010 | 26.7 (4.8) | 0.349 | 26.1 (6.4) | 0.008 |
| Comorbidities, n (%) | |||||||
| Atrial fibrillation | 237 (3.6) | 61 (5.7) | <0.001 | 1 (2.6) | 1.000 | 5 (5.2) | 0.578 |
| Hypertension | 2063 (31.3) | 441 (41.4) | <0.001 | 15 (39.5) | 0.361 | 33 (34.0) | 0.637 |
| Myocardial infarction | 202 (3.1) | 59 (5.5) | <0.001 | 0 | 0.530 | 5 (5.2) | 0.365 |
| Stroke | 254 (3.9) | 82 (7.7) | <0.001 | 3 (7.9) | 0.381 | 5 (5.2) | 0.686 |
| Heart failure | 108 (1.6) | 37 (3.5) | <0.001 | 0 | 0.875 | 1 (1.0) | 0.943 |
| CKD Stages III–V | 618 (9.4) | 177 (16.6) | <0.001 | 4 (10.5) | 1.000 | 12 (12.4) | 0.399 |
| Diabetes | 735 (11.2) | 187 (17.5) | <0.001 | 3 (7.9) | 0.703 | 14 (14.4) | 0.383 |
| COPD | 466 (7.1) | 79 (7.4) | 0.683 | 1 (2.6) | 0.451 | 11 (11.3) | 0.146 |
| Asthma | 1118 (17.0) | 179 (16.8) | 0.906 | 4 (10.5) | 0.399 | 14 (14.4) | 0.594 |
| Malignancy | 369 (5.6) | 75 (7.0) | 0.031 | 2 (5.3) | 1.000 | 3 (3.1) | 0.390 |
| Metastatic cancer | 62 (0.9) | 17 (1.6) | 0.025 | 0 | 1.000 | 2 (2.1) | 0.534 |
| Depression | 1855 (28.1) | 234 (22.0) | <0.001 | 7 (18.4) | 0.248 | 21 (21.6) | 0.187 |
| Haematological/lab values, mean (s.d.) | |||||||
| Haemoglobin (g/L)d | 13.2 (1.5) | 11.6 (1.4) | <0.001 | 12.7 (1.8) | 0.020 | 12.2 (1.7) | <0.001 |
| Neutrophil count (109/L)d | 4.7 (2.6) | 5.0 (2.5) | <0.001 | 1.3 (0.4) | <0.001 | 4.5 (2.7) | 0.483 |
| Lymphocyte count (109/L)d | 2.0 (1.0) | 1.7 (0.8) | <0.001 | 1.6 (0.6) | 0.008 | 0.6 (0.2) | <0.001 |
| Seropositivee | 1791 (27) | 269 (25) | 0.129 | 13 (34) | 0.427 | 21 (22) | 0.264 |
| Medications, n (%) | |||||||
| NSAIDs | 1962 (29.8) | 314 (29.5) | 0.836 | 10 (26.3) | 0.773 | 21 (21.6) | 0.099 |
| Glucocorticoids | 2001 (30.4) | 433 (40.6) | <0.001 | 7 (18.4) | 0.153 | 58 (59.8) | <0.001 |
| Methotrexate | 992 (15.1) | 197 (18.5) | 0.001 | 5 (13.2) | 0.921 | 22 (22.7) | 0.048 |
| Other csDMARDs | 1263 (19.2) | 260 (24.4) | <0.001 | 6 (15.8) | 0.747 | 42 (43.3) | <0.001 |
| bDMARDs | 19 (0.3) | 2 (0.2) | 0.721 | 0 (0.0) | 1.000 | 1 (1.0) | 0.674 |
a
P-value for differences when compared with those without anaemia.
b
P-value for differences when compared with those without neutropenia.
c
P-value for differences when compared with those without lymphopenia.
d
Missing baseline data: BMI, n = 520 (8%); haemoglobin, n = 499 (8%); neutrophils, n = 530 (8%); lymphocytes, n = 526 (8%).
e
Based on RF or anti-CCP antibody (%).
bDMARDs, biological DMARDs; csDMARDs, conventional synthetic DMARDs.