Table 3.
Adjusted HRs of infections by the presence or absence of haematological abnormality at baseline
| Abnormality | No haematological abnormality (n = 5499) | Anaemia (n = 1066) | Neutropenia (n = 38) | Lymphopenia (n = 97) |
|---|---|---|---|---|
| Infection events, n (%) | 3506 (53.2) | 658 (61.7) | 19 (50.0) | 73 (75.3) |
| Exposure time, person-years | 20 384 | 3631 | 125 | 285 |
| Event rate per 1000 person-years, median (IQR) | 172.0 (166.4–177.8) | 181.2 (167.7–195.6) | 151.8 (91.4–237.0) | 256.4 (201.0–322.4) |
| Unadjusted HR (95% CI) | Reference | 1.09 (1.00, 1.18) | 0.90 (0.54, 1.41) | 1.49 (1.18, 1.88) |
| Adjusted HR (95% CI)a | Reference | 1.19 (1.08, 1.30) | 1.06 (0.67, 1.67) | 1.41 (1.11, 1.79) |
a
Adjusted for age, sex, ethnicity (white/missing or non-white), baseline measures of other haematological measures, BMI category (<18.5 underweight, 18.5–24.9 normal weight, 25.0–29.9 overweight, 30.0–34.9 class I obesity, 35.0–39.9 class II obesity, ≥40.0 class III obesity, missing), smoking status (never, current, former, missing), seropositivity (presence of RF or anti-CCP antibodies), medication use and comorbidities (see Table 1).
IQR, interquartile range.