Table 4.
HRs of infections by time-varying haematological abnormality status across study follow-up
| Status | Anaemia | Neutropenia | Lymphopenia |
|---|---|---|---|
| Individuals with at least one episode across follow-up, n | 2220 | 259 | 562 |
| Unadjusted HR (95% CI) | 1.13 (1.04, 1.24) | 1.10 (0.74, 1.63) | 1.46 (1.17, 1.81) |
| Adjusted HR (95% CI)a | 1.21 (1.10, 1.33) | 1.19 (0.80, 1.76) | 1.39 (1.12, 1.73) |
HRs represent the increase in the risk of infections associated with the presence of each haematological abnormality at any time during study follow-up compared with the absence of the haematological abnormality in the total study population with RA (n = 6591; infection events, n = 3506).
Adjusted for age, sex, ethnicity (white/missing or non-white), baseline measures of other haematological measures, BMI category (<18.5 underweight, 18.5–24.9 normal weight, 25.0–29.9 overweight, 30.0–34.9 class I obesity, 35.0–39.9 class II obesity, ≥40.0 class III obesity, missing), smoking status (never, current, former, missing), seropositivity (presence of RF or anti-CCP antibodies), medication use and comorbidities (see Table 1).