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. 2020 Dec 31;151(2):293–302. doi: 10.1093/jn/nxaa355

TABLE 2.

Top single nucleotide polymorphism from 14 loci associated with changes in selenium concentrations

Chromosome Position Changes in Se Concentration2 Baseline Se Concentrations3
SNP Gene1 Allele MAF2 β SE P β SE P
rs56856693 9:126 971 353 NEK6: Upstream Variant T/C 0.156 18.500 3.606 4.41 × 10−7 −0.007 0.004 0.09
rs34918453 3:1 161 939 CNTN6: Intron Variant G/A 0.306 12.700 2.568 2.67 × 10−6 0.0006 0.003 0.86
rs79133495 1:90 047 900 LRRC8B: Intron Variant T/A 0.052 28.200 5.928 2.71 × 10−6 −0.002 0.007 0.81
rs10417091 19:1 287 387 EFNA2: Intron Variant A/C 0.089 22.830 4.814 2.91 × 10−6 −0.007 0.006 0.19
rs439667 11:8 259 358 LMO1: Intron Variant C/G 0.276 −13.190 2.809 3.62 × 10−6 −0.0007 0.004 0.84
rs2700036 12:30 415 409 IPO8: Upstream Variant C/G 0.314 −13.400 2.868 4.00 × 10−6 −0.004 0.003 0.29
rs916856 7:27 936 243 JAZF1: Intron Variant C/T 0.408 11.620 2.552 6.96 × 10−6 0.003 0.003 0.42
rs652187 7:17 525 702 LOC101927630: Intron Variant A/G 0.426 11.680 2.566 6.96 × 10−6 0.003 0.003 0.42
rs17411601 8:19 977 043 SLC18A1: Upstream Variant T/G 0.389 11.950 2.642 7.95 × 10−6 −0.005 0.003 0.17
rs11953563 5:14 062 069 TRIO: Upstream Variant T/C 0.440 −11.690 2.596 8.73 × 10−6 −0.002 0.003 0.49
rs4840475 8:10 152 599 MSRA: Intron Variant T/C 0.312 12.320 2.740 9.00 × 10−6 −0.001 0.003 0.66
rs73125921 3:83 841 917  — T/G 0.084 −22.980 5.116 9.13 × 10−6 0.009 0.006 0.13
rs6498246 16:11 887 169 ZC3H7A: Intron Variant A/G 0.156 −15.230 3.391 9.14 × 10−6 0.001 0.004 0.88
rs6438565 3:119 870 658 GPR156: Intron Variant T/C 0.395 11.700 2.617 9.99 × 10−6 −0.0001 0.003 0.99

Data are after 1 year of selenium supplementation in the selenium-supplemented group (n = 428). SNPs with P < 1.00 × 10−5 were ordered based on the strength of significance for changes in Se concentrations. Abbreviations: MAF, minor allele frequency; PC, principal component; Se, selenium; SNP, single nucleotide polymorphism.

1

Gene is closest to the identified variants.

2

Adjusting for age at enrollment, sex, BMI, basal plasma Se concentrations, and the first 3 PCs.

3

Adjusting for age at enrollment, sex, and the first 3 PCs.