TABLE 3.

Associations between selenium-related single nucleotide polymorphisms and changes in plasma selenium concentrations

SNP1	Gene	Chromosome: Position	Allele	MAF	β	SE	P
GWAS
rs11960388	DMGDH	5:78 348 209	A/T	0.119	10.030	4.046	0.01
rs6887869	DMGDH	5:78 345 885	C/G	0.119	10.030	4.046	0.01
rs17823744	DMGDH	5:78 344 976	G/A	0.121	9.439	4.047	0.02
rs921943	DMGDH	5:78 316 476	T/C	0.286	5.047	2.745	0.07
rs11745652	IPO11	5:62 038 924	T/C	0.161	−1.520	3.557	0.67
rs2916143	PITPNC1	17:65 504 830	G/C	0.137	2.406	3.901	0.54
rs6859667	HOMER1	5:78 745 042	C/T	0.042	12.610	6.179	0.04
rs6586282	CBS	21:44 478 497	T/C	0.186	−0.590	3.559	0.87
Candidate gene
rs1050450	GPX1	3:49 394 834	A/G	0.305	−0.314	2.781	0.91
rs3877899	SELENOP	5:42 801 268	T/C	0.236	−3.943	3.124	0.21
rs2329999	SELENOP	5:42 849 236	T/G	0.299	−4.202	2.863	0.14
rs7160073	GPX2	14:65 450 630	T/G	0.366	1.741	2.769	0.53

Data are after 1 year of supplementation in the selenium-supplemented group (n = 428). Abbreviations: CBS, cystathionine beta-synthase; DMGDH, dimethylglycine dehydrogenase; GPX, glutathione peroxidase; GWAS, genome-wide association study; HOMER1, homer scaffold protein 1; IPO11, importin 11; MAF, minor allele frequency; PC, principal component; PITPNC1, phosphatidylinositol transfer protein cytoplasmic 1; SELENOP, selenoprotein P; SNP, single nucleotide polymorphism.

¹Adjusting for age at enrollment, sex, and the first 3 PCs.