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. 2021 Jan 13;47(3):21. doi: 10.3892/ijmm.2021.4854

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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NETs contribute to SARS-CoV-2-induced acute ischemic stroke by activating endothelial cells and platelets. SARS-CoV-2 enters blood vessels through the ACE2 receptor on cerebrovascular endothelial cells. The virus activates neutrophils to release NETs through a cytokine storm derived from activated macrophages. NETs initiate thrombosis by activating endothelial cells and platelets. NETs, neutrophil extracellular traps; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.