Table I.
Comparison of the coagulation indexes between patients with severe COVID-19 and those with non-severe infection.
| Author/(Refs.) | No. of patients | Severe infection | Non-severe infection | P-value |
|---|---|---|---|---|
| D-dimer (ng/ml) levels
| ||||
| Han et al (4) | 94 (49 ordinary, 35 severe, 10 critical) | Severe: 19,110±35,480 Critical: 20,040±32,390 |
2,140±2,880 | P<0.01 |
| Tang et al (5) | 183 (21 non-survivors, 162 survivors) | 2,120 (770-5,270) | 610 (350-1,290) | P<0.001 |
| Fan et al (85) | 73 (47 non-survivors, 26 survivors) | 1,510 (800-7,180) | 520 (310-1,120) | P<0.001 |
| Zou et al (86) | 303 (35 severe, 277 mild) | 1,040 (730-1,720) | 430 (310-770) | P<0.001 |
| Tang et al (58) | 449 (134 non-survivors, 315 survivors) | 4,700 (1,420-21,000) | 1,470 (780-4,160) | P<0.001 |
|
| ||||
| Fibrinogen (g/l)
| ||||
| Fogarty et al (87) | 83 (50 ICU 33 no ICU) | 5.6 (4.4-6.6) | 4.5 (3.7-6.2) | P=0.045 |
| Han et al (4) | 94 (49 ordinary, 35 severe, 10 critical) | Severe: 4.76±1.7301 Critical: 5.59±2.26 |
5.10±1.16 | P<0.01 |
| Tang et al (5) | 183 (21 non-survivors, 162 survivors) | 5.16 (3.74-5.69) | 4.51 (3.65-5.09) | P=0.149 |
| Zou et al (86) | 303 (35 severe, 277 mild) | 4.74 (4.21-5.84) | 4.33 (3.57-5.73) | P=0.038 |
|
| ||||
| Prothrombin time (sec)
| ||||
| Tang et al (5) | 183 (21 non-survivors, 162 survivors) | 15.5 (14.4-16.3) | 13.6 (13.0-14.3) | P<0.001 |
| Fan et al (85) | 73 (47 non-survivors, 26 survivors) | 11.80 (10.9-12.9) | 11.1 (10.25-12.05) | P=0.016 |
| Zou et al (86) | 303 (35 severe, 277 mild) | 13.8 (13.4-14.8) | 13.4 (13.0-13.8) | P=0.003 |
| Tang et al (58) | 449 (134 non-survivors, 315 survivors) | 16.5±8.4 | 14.6±2.1 | P<0.001 |
|
| ||||
| Activated partial thromboplastin time (sec)
| ||||
| Tang et al (5) | 183 (21 non-survivors, 162 survivors) | 44.8 (40.2-51.0) | 41.2 (36.9-44.0) | P=0.096 |
| Zou et al (86) | 303 (35 severe, 277 mild) | 43.2 (41.0-49.7) | 39.2 (36.3-42.4) | P<0.001 |
| Huang et al (88) | 41 (13 ICU, 28 no ICU) | 26.2 (22.5-33.9) | 27.7 (24.8-34.1) | P=0.57 |
| Wu et al (89) | 201 (117 no ARDS, 84 ARDS) | 26 (22.55-35) | 29.75 (25.55-32.85) | P=0.130 |
| 84 (40 ARDS alive, 44 ARDS died) | 24.10 (22.55-8.35) | 29.60 (24-35.75) | P=0.040 | |
|
| ||||
| Platelet count (×109 per l)
| ||||
| Fan et al (85) | 73 (47 non-survivors, 26 survivors) | 168 (136-221) | 204 (149-268) | P=0.054 |
| Tang et al (58) | 449 (134 non-survivors, 315 survivors) | 178±92 | 231±99 | P<0.001 |
| Huang et al (88) | 41 (13 ICU, 28 no ICU) | 196 (165-263) | 149 (131-263) | P=0.45 |
| Wu et al (89) | 201 (117 no ARDS, 84 ARDS) | 187 (124.50-252.50) | 178 (140-239.50) | P=0.73 |
| 84 (40 ARDS alive, 44 ARDS died) | 162 (110.5-231) | 204 (137.25-262.75) | P=0.1 | |
|
| ||||
| Fibrinogen degradation products (mg/l)
| ||||
| Han et al (4) | 94 (49 ordinary, 35 severe, 10 critical) | Severe: 60.01±108.98 Critical: 69.15±129.19 |
7.92±11.38 | P<0.01 |
| Tang et al (5) | 183 (21 non-survivors, 162 survivors) | 7.6 (4.0-23.4) | 4.0 (4.0-4.3) | P<0.001 |
| Zou et al (86) | 303 (26 severe, 277 mild) | 2.61 (1.44-4.48) | 0.99 (0.52-1.98) | P<0.001 |
ICU, intensive care unit; ARDS, acute respiratory distress syndrome.