Table 1.
Characteristics of the controls, RA and SLE patients in the AMI cohort
| Characteristicsa | Controls (n = 189 922) | Patients with autoimmune diseases | |||
|---|---|---|---|---|---|
| RA patientsb (n = 748) | P-valuec | SLE patientsb (n = 256) | P-valuec | ||
| Age, median (IQR), years | 70.0 (58.0–79.0) | 71.0 (64.0–78.0) | <0.0001 | 53.5 (42.0–67.0) | <0.0001 |
| Sexd | <0.0001 | <0.0001 | |||
| Female | 59 514 (31.3) | 472 (63.1) | 190 (74.2) | ||
| Male | 130 286 (68.6) | 276 (36.9) | 66 (25.8) | ||
| Medical comorbidities | |||||
| Hypertension | 112 353 (59.2) | 484 (64.7) | 0.002 | 169 (66.0) | 0.03 |
| Diabetes mellitus | 74 606 (39.3) | 255 (34.1) | 0.004 | 43 (16.8) | <0.0001 |
| Hyperlipidaemia | 52 592 (27.7) | 135 (18.1) | <0.0001 | 51 (19.9) | 0.006 |
| HF | 47 745 (25.1) | 229 (30.6) | 0.0006 | 63 (24.6) | 0.85 |
| CKD | 14 138 (7.4) | 50 (6.7) | 0.43 | 63 (24.6) | <0.0001 |
| ESRD | 8120 (4.3) | 21 (2.8) | 0.048 | 47 (18.4) | <0.0001 |
| PAD | 6269 (3.3) | 28 (3.7) | 0.50 | 13 (5.1) | 0.11 |
| Prior stroke | 38 055 (20.4) | 145 (19.4) | 0.66 | 39 (15.2) | 0.06 |
| COPD | 26 283 (13.8) | 123 (16.4) | 0.04 | 20 (7.8) | 0.005 |
| Dementia | 6434 (3.4) | 25 (3.3) | 0.95 | 1 (0.4) | 0.008 |
| Parkinson’s disease | 3352 (1.8) | 18 (2.4) | 0.18 | 1 (0.4) | 0.10 |
| AFib | 17 086 (9.0) | 67 (9.0) | 0.97 | 10 (3.9) | 0.004 |
| Gout | 15 914 (8.4) | 97 (13.0) | <0.0001 | 18 (7.0) | 0.44 |
| Reperfusion procedures | 85 643 (45.1) | 303 (40.5) | 0.01 | 131 (51.2) | 0.051 |
| PCI | 79 365 (41.8) | 285 (38.1) | 123 (48.1) | ||
| CABG | 7349 (3.9) | 19 (2.5) | 10 (3.9) | ||
| Hospital level | 0.21 | <0.0001 | |||
| Tertiary referral centre | 63 441 (33.4) | 276 (36.9) | 163 (63.7) | ||
| Regional hospital | 77 260 (40.7) | 294 (39.3) | 56 (21.9) | ||
| Other hospitals | 49 221 (25.9) | 178 (23.8) | 37 (14.5) | ||
a
Data are expressed as patient number (percentage) unless otherwise indicated.
b
Nine patients with a combination of RA and SLE were counted in the groups of patients with RA and SLE.
c
The P-values were calculated by comparison with the controls.
d
Sex data were missing or undetermined in 122 control patients (0.06%). AMI: acute myocardial infarction; IQR: interquartile range; HF: heart failure; CKD: chronic kidney disease; ESRD: end-stage renal disease; PAD: peripheral artery disease; COPD: chronic obstructive pulmonary disease; AFib: atrial fibrillation; PCI: percutaneous coronary intervention; CABG: coronary artery bypass grafting.