Table 2.
Risks of adverse events after AMI associated with RA and SLE
| Adverse outcomes | Controls (n = 189 922) | Patients with autoimmune diseases | |
|---|---|---|---|
| RA patients (n = 748) | SLE patients (n = 256) | ||
| In-hospital mortality (%) | 23 439 (12.3) | 142 (19.0) | 41 (16.0) |
| Crude OR (95% CI) | 1.00 | 1.66 (1.39, 2.00) | 1.35 (0.97, 1.89) |
| Adjusted OR (95% CI)a | 1.00 | 1.61 (1.33, 1.95) | 2.31 (1.62, 3.28) |
| Overall mortality (%) | 100 045 (52.7) | 495 (66.2) | 134 (52.3) |
| Crude HR (95% CI) | 1.00 | 1.56 (1.43, 1.71) | 1.06 (0.89, 1.25) |
| Adjusted HR (95% CI)b | 1.00 | 1.51 (1.38, 1.65) | 1.94 (1.63, 2.29) |
| Ischaemic eventsc (%) | 55 693 (29.3) | 209 (27.9) | 74 (28.9) |
| Crude HR (95% CI) | 1.00 | 1.19 (1.04, 1.36) | 1.02 (0.81, 1.28) |
| Adjusted HR (95% CI)b | 1.00 | 1.23 (1.07, 1.41) | 1.25 (0.99, 1.57) |
| Re-AMI (%) | 35 191 (18.5) | 126 (16.8) | 48 (18.8) |
| Crude HR (95% CI) | 1.00 | 1.09 (0.92, 1.30) | 1.05 (0.79, 1.39) |
| Adjusted HR (95% CI)b | 1.00 | 1.13 (0.95, 1.35) | 1.42 (1.07, 1.89) |
| Revascularization (%) | 51 146 (26.9) | 146 (19.5) | 69 (27.0) |
| Crude HR (95% CI) | 1.00 | 0.85 (0.72, 1.00) | 1.02 (0.81, 1.29) |
| Adjusted HR (95% CI)b | 1.00 | 1.00 (0.85, 1.18) | 1.25 (0.99, 1.59) |
| Any MACEd (%) | 138 625 (73.0) | 595 (79.6) | 187 (73.1) |
| Crude HR (95% CI) | 1.00 | 1.28 (1.18, 1.39) | 1.01 (0.88, 1.17) |
| Adjusted HR (95% CI)b | 1.00 | 1.28 (1.18, 1.38) | 1.46 (1.27, 1.69) |
Based on the multiple logistic regression analysis with adjustment for age, sex, medical comorbidities (hypertension, diabetes mellitus, hyperlipidaemia, heart failure, chronic kidney disease, peripheral artery disease, chronic obstructive pulmonary disease, dementia, Parkinson’s disease, atrial fibrillation and gout), reperfusion procedures and hospital levels.
Based on the Cox proportional hazards regression model with adjustment for age, sex, medical comorbidities (hypertension, diabetes mellitus, hyperlipidaemia, heart failure, chronic kidney disease, peripheral artery disease, chronic obstructive pulmonary disease, dementia, Parkinson’s disease, atrial fibrillation and gout), reperfusion procedures and hospital levels.
Ischaemic events were defined as rehospitalizations due to acute coronary syndrome after discharge.
The composite endpoint MACE was defined as any occurrence of all-cause mortality, myocardial infarction and revascularization after AMI. AMI: acute myocardial infarction; OR: odds ratio; HR: hazard ratio; MACE: major adverse cardiac events.