Table 1.
Baseline characteristics of ‘prospective investigation group’ patients and ‘historical control group’ patients
| Characteristic | Prospective investigation group (N = 25) | Historical control group (N = 16) |
|---|---|---|
| Age (years), mean (s.d.) | 55.4 (12.0) | 51.2 (12.0) |
| Female sex, n (%) | 19 (76.0) | 14 (87.5) |
| Duration of IIM (months), mean (s.d.) | 1.47 (4.03) | 0.49 (0.89) |
| Idiopathic inflammatory myopathies, n (%) | ||
| PM | 7 (28.0) | 7 (43.8) |
| DM | 12 (48.0) | 8 (50.0) |
| Clinically amyopathic DM | 6 (24.0) | 1 (6.3) |
| Anti-Jo-1 antibody, n (%) | 6 (24.0) | 13 (81.3) |
| CK (IU/l), mean (s.d.) | 948.2 (1259.0) | 2407.0 (3060.9) (N = 15)a |
| KL-6 (U/l), mean (s.d.) | 1118.8 (740.3) | 1119.2 (764.0) (N = 14)a |
| SP-D (μg/ml), mean (s.d.) | 182.8 (132.7) | 118.0 (56.0) (N = 9)a |
| Duration of interstitial pneumonitis (months), mean (s.d.) | 2.51 (7.33) | 1.24 (1.26) |
| FVC (% of predicted), mean (s.d.) | 69.1 (14.0) | 70.7 (19.1) (N = 13)a |
| DLCO (% of predicted), mean (s.d.) | 43.7 (8.7) | 50.1 (12.1) (N = 10)a |
| PaO2 at rest (room air) (mmHg), mean (s.d.) | 79.5 (14.2) | 82.4 (8.9) (N = 13)a |
| AaDO2 at rest (mmHg), mean (s.d.) | 29.5 (33.0) | 20.9 (18.7) (N = 13)a |
| Score on Mahler Baseline Dyspnoea Index, mean (s.d.) | 6.3 (2.5) | NA |
| Score for HAQ disability index, mean (s.d.) | 0.95 (0.74) | NA |
| SF-36v2 Health Survey score, mean (s.d.) | ||
| Physical functioning score | 48.8 (22.9) | NA |
| Role-physical score | 42.0 (27.8) | NA |
| Bodily pain score | 48.5 (29.2) | NA |
| General health perception score | 50.1 (14.3) | NA |
| Vitality score | 35.8 (23.3) | NA |
| Social functioning score | 46.0 (28.1) | NA |
| Role-emotional score | 50.0 (30.4) | NA |
| Mental health score | 49.6 (23.4) | NA |
| Whole-lung high attenuation scoreb | 52.2 (26.2) | 38.9 (23.0) (N =14)a |
| Radiographically speculated histological type, n (%)c | ||
| UIP | 1 (4.0) | 0 (0.0) |
| NSIP | 23 (92.0) | 15 (93.8) |
| OP | 1 (4.0) | 0 (0.0) |
| DAD | 0 (0.0) | 0 (0.0) |
Scores for the Mahler Baseline Dyspnoea Index can range from 0 to 12, with lower scores indicating worse dyspnoea. Scores for the HAQ disability index can range from 0 to 3, with higher numbers indicating greater disability. Scores for SF-36v2 Health Survey can range from 0 to 100, with lower scores indicating worse health status.
Some baseline clinical data for historical control group patients were not available.
Detailed description of the analytic method for high-resolution CT images are provided in the supplementary material, section Analysis of HRCT Images, available at Rheumatology online.
Some patients had more than one histopathological subtype speculated by independent radiologists. For example, one patient had OP and NSIP speculated. This table shows only the most dominant subtype in each patient. IIM: idiopathic inflammatory myopathies; CK: creatine kinase; KL-6: Krebs von den Lungen 6; SP-D: surfactant protein D; FVC: forced vital capacity; DLCO: diffusing capacity for carbon monoxide; AaDO2: alveolar-arterial oxygen gradient; UIP: usual interstitial pneumonia; NSIP: non-specific interstitial pneumonia; OP: organizing pneumonia; DAD: diffuse alveolar damage; NA: not available.