Table 2.

Adverse events of any grade with a frequency >10%

AEs, n (%)	320 mg q.d. N = 20		480 mg q.d. N = 7		480 mg q.d., Fasted N = 17		All N = 44
	All Grades	Grade ≥3	All Grades	Grade ≥3	All Grades	Grade ≥3	All Grades	Grade ≥3
Any AEs	16 (80.0)	6 (30.0)	7 (100.0)	5 (71.4)	15 (88.2)	10 (58.8)	38 (86.4)	21 (47.7)
Rash	6 (30.0)	0	2 (28.6)	0	6 (35.3)	1 (5.9)	14 (31.8)	1 (2.3)
Neutropenia	4 (20.0)	2 (100)	2 (71.4)	0	4 (20.0)	2 (11.8)	10 (22.7)	4 (9.1)
Leukopenia	2 (10.0)	1 (5.0)	3 (42.9)	0	3 (17.6)	2 (11.8)	8 (18.2)	3 (6.8)
Lymphopenia	2 (10.0)	0	3 (42.9)	2 (28.6)	2 (11.8)	1 (5.9)	7 (15.9)	3 (6.8)
Thrombocytopenia	1 (5.0)	0	3 (42.9)	0	1 (5.9)	0	5 (11.4)	0
Erythema multiforme	2 (10.0)	1 (5.0)	3 (42.9)	2 (28.6)	0	0	5 (11.4)	3 (6.8)
Constipation	1 (5.0)	0	0	0	4 (23.5)	0	5 (11.4)	0
Drug eruption	2 (10.0)	1 (5.0)	1 (14.3)	1 (14.3)	1 (5.9)	0	4 (9.1)	2 (4.5)
Blood bilirubin increased	4 (20.0)	1 (5.0)	0	0	0	0	4 (9.1)	1 (2.3)
Nausea	1 (5.0)	0	1 (14.3)	0	2 (11.8)	1 (5.9)	4 (9.1)	1 (2.3)
Stomatitis	2 (10.0)	0	1 (14.3)	0	1 (5.9)	0	4 (9.1)	0
Anemia	1 (5.0)	0	1 (14.3)	0	2 (11.8)	0	4 (9.1)	0
Vomiting	1 (5.0)	0	0	0	3 (17.6)	0	4 (9.1)	0
Aspartate aminotransferase  increased	2 (10.0)	1 (5.0)	0	0	1 (5.9)	1 (5.9)	3 (6.8)	2 (4.5)
Hypertriglyceridemia	0	0	0	0	3 (17.6)	2 (11.8)	3 (6.8)	2 (4.5)
Dyslipidemia	1 (5.0)	0	1 (14.3)	0	1 (5.9)	1 (5.9)	3 (6.8)	1 (2.3)
Seizure	1 (5.0)	0	0	0	2 (11.8)	1 (5.9)	3 (6.8)	1 (2.3)
Rash maculopapular	1 (5.0)	0	0	0	2 (11.8)	1 (5.9)	3 (6.8)	1 (2.3)
Urinary tract infection	0	0	2 (28.6)	0	1 (5.9)	1 (5.9)	3 (6.8)	1 (2.3)
Headache	2 (10.0)	0	1 (14.3)	0	0	0	3 (6.8)	0