TABLE 4.

Univariate and Multivariate Binary Logistic Regression Results for Identifying Factors Associated With Hemodynamic Response

Factor	Crude Odds Ratio	95% CI for Odds Ratio	Adjusted Odds Ratio	95% CI for HR
Age (years)	1.01	0.99, 1.03
Gender (female)	1.15	0.72, 1.83
Etiology (ref = others)
Alcohol	0.72	0.47, 1.10
Viral	0.76	0.49, 1.17
Diabetes	0.88	0.41, 1.89
Hypertension	0.42	0.04, 4.04
BMI (kg/m2) (ref = 18.5‐25)
<18.5	0.49	0.15, 1.59
25‐30	1.23	0.82, 1.85
≥30	1.03	0.63, 1.68
MELD	0.98	0.95, 1.01
CTP	0.84*	0.75, 0.94
Ascites (ref = no ascites)
Grade 1	0.79	0.47, 1.32
Grade 2 and 3	0.51 †	0.28, 0.91
eGFR (mL/min)	1.34	0.94, 1.90
MAP	1.02	1.00, 1.03
Beta‐blocker	3.10*	1.39, 6.92	3.35*	1.49, 7.54
HVPG (>17 mm Hg)	1.21	0.85, 1.74
SVRI (>2,008 dyn$\bullet$s/cm5/m2)	2.11*	1.35, 3.29	2.04*	1.29, 3.22
PVRI (>68 dyn$\bullet$s/cm5/m2)	0.99	0.66, 1.47
CRDI (>4 L/min/m2)	1.17	0.76, 1.79
Leucocyte counts ‡ (×103/m3)	1.15	0.81, 1.63
Serum bilirubin ‡ (mg/dL)	0.93	0.77, 1.11
Serum albumin (g/dL)	1.80*	1.34, 2.41
INR (seconds)	0.57 †	0.35, 0.94
Serum creatinine at enrollment (mg/dL)	1.52	0.71, 3.24
Serum sodium (mEq/L)	1.06*	1.02, 1.10
MELD‐Na	0.96*	0.94, 0.99	0.97 †	0.94, 1.00

MELD‐Na was calculated using bilirubin, INR, creatinine, and sodium. Therefore, these components were not considered for the multivariate regression model, as MELD‐Na was included in the model. Also, because CTP is highly associated with MELD‐Na, CTP was not considered for the multivariate analysis, to avoid multicollinearity. PVRI, CRDI, and MAP were not included in the multivariate analysis, as they are highly associated with SVRI. HVPG, SVRI, PVRI, and CVRI were considered as category variables in the regression analysis. Variables considered in multivariate analysis were use of BBs, SVRI, and MELD‐Na.

^*Significant at 1% level of significance.

^†Significant at 5% level of significance.

^‡Corresponding log‐transformed variables were used in the regression analysis.