Table 2.

ZIKV Drugs Targeting Viral Proteins

Targets	Inhibitors	IC 50 µM	ZIKV Strains	Cell lines tested	Biochemical Assays	Animal tests	Pregnancy Category	Reference
Envelope	EGCG	21.4	ZIKVBR, MR 766	Vero E6	Cell viability	Wistar (SPF) rats	-	[115,156]
	Crotoxin	0.23, 0.32 µg/µl	-	Vero E6, C6/36	WB	BALB/c	-	[114]
	Pinocembrin	17.4	PRAVBC59	JEG-3	WB,QRT-PCR,IFA,TOA	-	Phase 1 Trials	[117]
	Psiloxylon mauritianum	19.5 µg/ml	MR766, ZIKV PF-13	Vero, A549	TOA, IFA, RT-qPCR, FISH, Flow cytometry, COMET	-	-	[157]
	Porphyrins (Co-protoporphyrin IX (CoPPIX) and Sn-protoporphyrin IX (SnPPIX)	2.49, 5.78	MR766, ZIKVBR	BHK-21, Vero, HeLa,	TOA, IFA, TEM, WB, ELISA	Rats and humans	-	[116]
	Suramin	47	BeH823339	-	DSC, NMR	C57BL/6	-	[118,119]
	Ivermectin	~5.00	MEX_1_7/2015	Huh-7, HeLa, NPC, JEG3, HAEC	Flow cytometry, IFA	C57BL/6 J	-	[120,121]
NS5 polymerase	BCX4430	3.8 ± 2.5, 4.7 ± 0.6, 4.7 ± 2.2	PRVABC59	Vero76, Huh-7, RD	Immunohistochemistry(IHC), qRT-PCR	AG129 mice, Rhesus macaques	Phase 1 trials	[158]
	7DMA	1.3	MR766	Vero, BHK, C6/36	TOA, IFA, RT-PCR	AG129 mice	-	[46]
	Emetine	0.0298	MR 766, PRAVBC59, FSS13025	SNB-19, HEK 293, Vero E6, hNSC	Western blot(WB), IF	AG129 and SJL mice	-	[109]
	Cephaeline	0.0189	MR 766, PRAVBC59, FSS13025	SNB-19, HEK 293, Vero E6, hNSC	WB, IF, NS5 polymerase inhibition	AG129 and SJL mice	-	[109]
	Ribavirin	Unknown	MR766, PRVABC59, and PC-740	A549, hNPCs, HDFs and Vero	MTT assay, qRT-PCR, western-blot	129 SV	-	[110,135]
	Sofosbuvir	unknown	ZIKVBR, MR766	VeroE6	Cell viability, Caspase assay	Swiss Albino mice	B	[131]
	Favipiravir	-	PRVVABC59, P6-740	Vero. hNPCs	qRT-PCR, WB, IFA	129 SV	-	[110,135]
NS5 Methyltransferase	SAM analog sinefungin, S-adenosyl-L-homocysteine (SAH	1.18, 0.43	H/PF/2013	unknown	Radioactive methyltransferase assay	ND	-	[159]
	F3043-0013, F0922-0796, F1609-0442, and F1750-0048	4.8 ± 2.4, 12.5 ± 7.4, 17.5 ± 8.4 and 17.6 ± 3.1	-	Vero	Plaque Reduction Assay	ND	-	[132]
NS2B/NS3	Lopinavir-ritonavir	4.78$\pm 0.41\mu$g/ml	PRVABC59	Vero, Huh-7, in silico	NS2B-NS3 protease activity	-	B	[123]
	Novobiocin	42.63, 62.24	PRVVABC59	Vero, Huh-7, in silico	NS2B-NS3 protease activity	BALB/c mice	C	[123]
	Aprotinin	0.361$\pm 19$	Z1106033	in silico	X-ray crystallography	-	B	[125]
	Bromocriptine	13.04$\pm 2.00$	PRVABC59	Vero	NS2B-NS3 protease assay	-	B	[126]
	NSC135618	1.0	PRVABC59	A549, hNPCs, HPEC,	IFA, qRT-PCR,WB, mass spectrometry	-	-	[160]
	Peptide Z2	1.75	SZ01/2016, GZ01/2016	C6/36, Vero, Huh-7	IFA, flow cytometry, RT-qPCR,	C57BL/6 mice	-	[161]
	Erythrosin B	0.62 ± 0.12	PRVABC59	HPECs, A549, HNPC	IFA, qRT-PCR, protein thermal shift assay, WB	-	B	[124]
	Temoporfin, Niclosamide, Nitazoxanide	0.024, 0.48, 1.48	PRVABC59	A549, HPECs, hNPCs	IFA, WB, qRT-PCR, SPR	-	-	[107]
	NSC157058, NSC86314, NSC716903	0.82 ± 0.09, 1.12 ± 0.11, 3.01	FSS13025	hfNPCs	Fluorescent peptide, IF, RT-PCR	-	-	[162]
	Myricitin, Quercetin, Luteolin, Isorhamnetin and Apigerin	1.3 ± 0.1, 2.4 ± 0.2, 2.7 ± 0.3, 15.5 ± 0.7, 56.3 ± 0.9 and 3.5 ± 0.2	ZIKV 8375	-	NMR	-	-	[122]