Table 2.
Multifunctional light-responsive DDSs for HNC therapy.
| DDS carriers | Anticancer agentsa | Functions | Refs. |
|---|---|---|---|
| Fibronectin-mimetic peptide conjugated ION | Photosensitizer (Pc 4) | Tumor targeting; MRI imaging and PDT | Wang, Fei, et al. (2014) |
| Self-assembled core–shell nanoparticles | CDDP; pyrolipid | Chemotherapy and PDT | He et al. (2015) |
| Polyglutamate nanoparticles | ICG | PDT and PTT | Tarassoli et al. (2017) |
| Human serum albumin nanoparticles | ICG; CDDP | Tumor targeting; PDT, PTT and chemotherapy | Wang, Xie, et al. (2019) |
| RGDfK peptide conjugated calcium phosphate nanoparticles | Temoporfin; fluorescent dye molecule (DY682-NHS) | Tumor targeting; NIR fluorescence imaging and PDT | Haedicke et al. (2015) |
| Gold nanorods | siRNA oligos | Gene therapy and PTT | Wang, Yu, et al. (2016) |
| Evans blue derivative-functionalized gold nanorods | Hydroxycamptothecin | tumor targeting; PTT and chemotherapy | Wang et al. (2018) |
| PDPN antibody-conjugated gold nanoparticles | DOX | tumor targeting; PTT and chemotherapy | Liu et al. (2020) |
| Gold nanorods | Rose Bengal molecules | PDT and PTT | Wang, Wang, et al. (2014) |
| Au nanoring | Sulfonated aluminum phthalocyanines | PDT and PTT | Chu et al. (2016) |
aThe anticancer agents are shown in the following abbreviations: CDDP: cisplatin; ICG: indocyanine green; DOX: doxorubicin.