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. 2021 Jan 27;13:773–785. doi: 10.2147/CMAR.S281969

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© 2021 Guo et al.

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BMP2 knockdown inhibits the proliferation, migration and invasion of CSCs in HCC via inhibiting the MAPK/ERK pathway. (A) WB was used to detect the levels of p-ERK1/2, ERK1/2, MEK1/2 and p-MEK1/2; (B) The effect of MAPK/ERK pathway inhibitor on the colony-forming ability of liver CSCs was detected using colony formation assay; (C) The effect of MAPK/ERK pathway inhibitor on the sphere-forming rate of liver CSCs was detected using sphere formation assay; (D) The effect of the MAPK/ERK pathway on the colony-forming ability of liver CSCs was detected using the colony formation assay; (C) The effect of the MAPK/ERK pathway on the sphere-forming ability of hepatic CSCs was detected using sphere formation assay. The cell experiment was repeated three times, and the data were expressed as mean ± standard deviation. Data in panels (D and E) were analyzed using independent t-test, data in panels (B and C) were analyzed using one-way ANOVA and data in the panel (A) were analyzed using two-way ANOVA, followed by Tukey’s multiple comparisons test. * p < 0.05; ** p < 0.01.