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. 2021 Feb 1;16(2):e0245827. doi: 10.1371/journal.pone.0245827

Fig 3.

Fig 3

Patient-reported outcomes (ITT population): A) PGIC across time points. B) Mean NRS-Pain scores across time points. C) Mean BPI scores across time points. D) Level of depressive (PHQ-9) mood across time points. E) Change from baseline in CDIP-58 scaled sum total score across time points. BPI = Brief Pain Inventory; CDIP-58 = Cervical Dystonia Impact Profile-58; ITT = intent-to-treat (all randomized patients); Improved = minimally, much, or very much improved; Last available* = last available post-baseline (end of study or early withdrawal); Mild/moderate = mild depression (5‒9) or moderate depression (10‒14); No/minimal = no depression (0) or minimal depression (1‒4); NRS-Pain = numeric rating scale for pain; Worse = minimally, much, or very much worse; PGIC = Patient Global Impression of Change; PHQ-9 = Patient Health Questionnaire-9; Severe = moderately severe depression (15‒19) or severe depression (20–27). * Last available = last available post-baseline (end of study or early withdrawal), mean (SD) study drug exposure: 62.6 (37.8) days.