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. 2021 Feb 1;17(2):e1009164. doi: 10.1371/journal.ppat.1009164

Fig 5. K25 is not required to interact with E29 in hexamers or pentamers.

Fig 5

(a) IP5:CA hexamer structure showing the location of K25, E28, E29 and K30. Only the second IP5 molecule in proximity to K25 is depicted. Dotted lines indicate potential interactions. (b) Model of an IP5:CA pentamer, generated using monomers from the hexamer in (a) and the pentamer cryo-EM structure 5MCY[22]. (c) Infectivity of WT HIV and selected mutants. Infectivity is measured using an IncuCyte and determined as the proportion of cell area that is GFP +ve at a given viral dose (in ng RT). Error bars in infection experiments depict mean ± SD of three replicates from one experiment representative of three independent experiments.