Table 1. Nondimensional parameter values used in this work unless indicated otherwise.
Parameter | Meaning | Value |
---|---|---|
Da | Diffusion constant of active nucleators | 4 ⋅ 10−2 |
va | Effective actin polymerization speed | 0.1–0.6 |
kd | Effective filament degradation rate | 176 |
ω | Cooperative binding strength of nucleators | 6 ⋅ 10−3 |
ωd | Detachment rate of active nucleators | 0.1 − 0.6 |
α | Actin polymerization rate | 588 |
ntot | Average total nucleator density | 700 |
L | System length | 1.3 |
Ng | Number of grid points per dimension | 256 |
Time scale | 91.6 s | |
Length scale | 63.5 μm | |
DΨ | Phasefield relaxation / surface tension coefficient | 5 ⋅ 10−3 |
κ | Phasefield timescale modifier | 118 |
ϵ | Area conservation strength | 8 |
β | Actin-membrane interaction coefficient | 5.75 ⋅ 10−3 |
A0 | Mean cell area | 0.083 |
The length and time scales are chosen such that the ensuing dynamics is comparable to that of immature dendritic cells [10].