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. 2020 Jun 18;72(3):495–498. doi: 10.1093/cid/ciaa809

Figure 1.

Figure 1.

Associations of HIV burden measures using the (IPDA and alternative assays. A, Matrix of between-assay associations. B, Correlations of intact HIV proviruses assessed by IPDA with total HIV DNA, and integrated HIV DNA measures (assessed by Alu-gag PCR and pulse-field gel electrophoresis and droplet digital PCR [PFGE/ddPCR] [HIV Gag, HIV Pol]). In panel A, numbers in each square indicate the number of participants used for each association; blue circles indicate associations with significant positive correlations with P< .05, <.01, <.001, and <.0001 listed with 1, 2, 3, or 4 asterisks inside the circle. Color of circles represent Spearman rho with negative correlations represented by shades of red and positive correlations represented by shades of blue with darker shades representing stronger rho. Panel B shows available data together with n, rho, and P values. Spearman rank correlation test was used for variables associations in patients with available data on correlated variables. P-values < .05 were considered statistically significant. Abbreviations: HIV, human immunodeficiency virus; IPDA, intact proviral DNA assay; PCR, polymerase chain reaction; SIMOA, single molecule array; TILDA, tat/rev-induced limiting dilution assay.