Table 2.
Function enrichment analysis for target genes of crucial miRNAs.
| Term | Genes | FDR | Count |
| GO:0045944∼positive regulation of transcription from RNA polymerase II promoter | CTNNB1, MAPK3, VEGFA, MAPK14, PIK3R1 | 3.89E−12 | 239 |
| GO:0000122∼negative regulation of transcription from RNA polymerase II promoter | CTNNB1, VEGFA, CCND1, CUL3 | 2.75E−07 | 172 |
| GO:0045893∼positive regulation of transcription, DNA-templated | CTNNB1, MAPK1, MAPK3, CDH1, IGF1 | 4.13E−07 | 132 |
| GO:0006468∼protein phosphorylation | MAPK1, MAPK3, MAPK8, CCND1, PIK3R1 | 1.79E−05 | 115 |
| GO:0048013∼ephrin receptor signaling pathway | CDC42, RHOA, EPHA8 | 4.66E−05 | 35 |
| GO:0007411∼axon guidance | BDNF, MAPK1, MAPK3, NRAS, EPHA8 | 2.09E−04 | 51 |
| GO:0006366∼transcription from RNA polymerase II promoter | MEF2C, AKNA, MEF2A, RNMT, LMO4, STAT5B, TBP, REST, FOXO3, FOXO4… | 2.15E−04 | 122 |
| GO:0035556∼intracellular signal transduction | MAPK14, MAP3K4, CRKL | 1.49E−03 | 98 |
| GO:0018105∼peptidyl-serine phosphorylation | MAPK1, MAPK14, MAPK3, MAPK8 | 6.29E−03 | 40 |
| GO:0061024∼membrane organization | SGCZ, YWHAZ, CCDC88A, PRKCI, CHP1, LPCAT2, YWHAE, YWHAG, YWHAH, YWHAQ… | 6.38E−03 | 17 |
| GO:0030182∼neuron differentiation | MEF2C, WNT5A, EDN3, COPS2, CDK5R1, WNT3A, MYEF2, HOXD1, ITM2C, WNT2… | 7.77E−03 | 33 |
| GO:0007165∼signal transduction | MAPK1, MAPK14, IGF1R, PIK3R1… | 2.59E−02 | 226 |
| hsa05205:Proteoglycans in cancer | CTNNB1, CDC42, RHOA, MAPK1, CCND1, VEGFA, MAPK3, IGF1R, PIK3R1, IGF1, NRAS, MAPK14 | 2.79E−07 | 68 |
| hsa04722:Neurotrophin signaling pathway | CDC42, BDNF, RHOA, PIK3R1, MAPK1, NRAS, MAPK14, MAPK3, MAPK8 | 1.79E−05 | 45 |
| hsa04010:MAPK signaling pathway | CDC42, BDNF, MAPK1, MAPK3, MAPK8, NRAS, MAPK14, MAP3K4 | 2.91E−05 | 75 |
| hsa05200:Pathways in cancer | CTNNB1, MAPK1, VEGFA, MAPK3, MAPK8, CDC42, RHOA, CCND1, CDH1, IGF1R, PIK3R1, IGF1, NRAS, LAMC1 | 6.93E−05 | 103 |
| hsa04360:Axon guidance | CDC42, RHOA, MAPK1, NRAS, EPHA8, MAPK3 | 1.25E−04 | 45 |
| hsa04022:cGMP-PKG signaling pathway | RHOA, MAPK1, MAPK3 | 1.65E−04 | 52 |
| hsa04151:PI3K-Akt signaling pathway | MAPK1, CCND1, VEGFA, MAPK3, IGF1R, PIK3R1, IGF1, NRAS, LAMC1 | 1.68E−04 | 92 |
| hsa04068:FoxO signaling pathway | IGF1R, PIK3R1, IGF1, MAPK1, NRAS, CCND1, MAPK14, MAPK3, MAPK8 | 7.11E−04 | 45 |
| hsa04510:Focal adhesion | CTNNB1, CDC42, RHOA, MAPK1, CCND1, VEGFA, MAPK3, MAPK8, IGF1R, PIK3R1, IGF1, LAMC1 | 7.61E−04 | 61 |
| hsa04014:Ras signaling pathway | CDC42, RHOA, MAPK1, MAPK3, VEGFA, MAPK8, IGF1R, PIK3R1, IGF1, NRAS | 9.62E−04 | 65 |
| hsa04152:AMPK signaling pathway | IGF1R, PIK3R1, CCND1, ELAVL1 | 1.11E−03 | 42 |
| hsa04310:Wnt signaling pathway | CTNNB1, RHOA, CCND1, MAPK8 | 1.77E−03 | 45 |
| hsa05220:Chronic myeloid leukemia | PIK3R1, NRAS, MAPK1, CCND1, MAPK3, CRKL | 2.02E−03 | 29 |
| hsa04015:Rap1 signaling pathway | CTNNB1, CDC42, RHOA, MAPK1, MAPK3, VEGFA, CDH1, IGF1R, PIK3R1, IGF1, NRAS, MAPK14, CRKL | 3.48E−03 | 60 |
| hsa04611:Platelet activation | RHOA, PIK3R1, MAPK1, MAPK14, MAPK3 | 5.52E−03 | 42 |
| hsa04666:Fc gamma R-mediated phagocytosis | CDC42, PIK3R1, MAPK1, MAPK3, CRKL | 6.84E−03 | 31 |
| hsa05214:Glioma | IGF1R, PIK3R1, IGF1, NRAS, MAPK1, CCND1, MAPK3 | 9.25E−03 | 26 |
| hsa05211:Renal cell carcinoma | CDC42, PIK3R1, NRAS, MAPK1, VEGFA, MAPK3, CRKL | 1.27E−02 | 26 |
| hsa04550:Signaling pathways regulating pluripotency of stem cells | CTNNB1, IGF1R, PIK3R1, IGF1, MAPK1, NRAS, MAPK14, MAPK3 | 1.72E−02 | 43 |
| hsa04520:Adherens junction | CDH1, CTNNB1, CDC42, IGF1R, RHOA, MAPK1, MAPK3 | 1.73E−02 | 27 |
| hsa04066:HIF-1 signaling pathway | IGF1R, PIK3R1, IGF1, MAPK1, VEGFA, MAPK3 | 1.76E−02 | 33 |
| hsa04120:Ubiquitin mediated proteolysis | UBE2Z, XIAP, UBE2G1, BTRC, UBA6, SAE1, UBE3C, UBE2R2, PRPF19, CUL3… | 2.32E−02 | 42 |
| hsa04114:Oocyte meiosis | IGF1R, IGF1, MAPK1, MAPK3 | 2.78E−02 | 36 |
| hsa04668:TNF signaling pathway | PIK3R1, MAPK1, MAPK14, MAPK3, MAPK8 | 3.03E−02 | 35 |
| hsa04012:ErbB signaling pathway | PIK3R1, MAPK1, NRAS, MAPK3, MAPK8, CRKL | 4.44E−02 | 30 |
FDR = false discovery rate, GO = Gene ontology, KEGG = Kyoto encyclopedia of genes and genomes. Only the hub genes enriched in GO or pathways were listed.