Table 3.
Topology measures for nodes of the PPI network.
| SC | DC | EC | IC | LAC | BC | CC | NC | ||||||||
| MAPK3 | 1.37E+21 | MAPK3 | 171 | MAPK3 | 0.19 | MAPK3 | 14.89 | UBE2Q1 | 30 | MAPK3 | 11987.87 | MAPK3 | 0.62 | MAPK3 | 117.18 |
| MAPK1 | 1.06E+21 | MAPK1 | 148 | MAPK1 | 0.17 | MAPK1 | 14.69 | UBE3C | 29.88 | MAPK1 | 9465.96 | MAPK1 | 0.59 | MAPK1 | 94.16 |
| VEGFA | 1.04E+21 | RHOA | 135 | VEGFA | 0.17 | RHOA | 14.55 | UBE2J1 | 29.88 | CTNNB1 | 9329.19 | CTNNB1 | 0.59 | RHOA | 86.82 |
| RHOA | 9.10E+20 | CTNNB1 | 134 | RHOA | 0.15 | CTNNB1 | 14.54 | IGF1 | 29.46 | RHOA | 7752.85 | VEGFA | 0.59 | VEGFA | 82.56 |
| CTNNB1 | 9.07E+20 | VEGFA | 133 | CTNNB1 | 0.15 | VEGFA | 14.53 | VEGFA | 29.05 | VEGFA | 6987.20 | RHOA | 0.58 | CTNNB1 | 79.70 |
| CDC42 | 8.33E+20 | CDC42 | 121 | CDC42 | 0.15 | CDC42 | 14.38 | UBE2Z | 28.97 | MAPK8 | 6486.17 | MAPK8 | 0.57 | CDC42 | 72.93 |
| MAPK8 | 8.15E+20 | MAPK8 | 120 | MAPK8 | 0.15 | MAPK8 | 14.36 | MAPK3 | 28.76 | CDC42 | 5282.59 | CDC42 | 0.57 | MAPK8 | 69.27 |
| PIK3R1 | 7.49E+20 | CDH1 | 109 | PIK3R1 | 0.14 | CDH1 | 14.20 | KLHL13 | 28.48 | CDH1 | 4037.51 | CDH1 | 0.57 | CDH1 | 61.09 |
| CDH1 | 7.42E+20 | PIK3R1 | 103 | CDH1 | 0.14 | PIK3R1 | 14.09 | UBE4A | 28.24 | PRKCA | 3062.30 | NRAS | 0.55 | PIK3R1 | 57.98 |
| IGF1 | 7.35E+20 | NRAS | 100 | IGF1 | 0.14 | NRAS | 14.04 | UBE2H | 28.24 | RAC1 | 2845.44 | PIK3R1 | 0.55 | IGF1 | 56.48 |
| CCND1 | 6.48E+20 | IGF1 | 97 | CCND1 | 0.13 | IGF1 | 13.98 | UBE2R2 | 28.24 | NRAS | 2794.93 | MAPK14 | 0.55 | NRAS | 53.36 |
| NRAS | 6.40E+20 | CCND1 | 94 | NRAS | 0.13 | CCND1 | 13.91 | FGF2 | 28.16 | SIRT1 | 2703.91 | IGF1 | 0.55 | CCND1 | 53.28 |
| IGF1R | 6.34E+20 | MAPK14 | 94 | IGF1R | 0.13 | MAPK14 | 13.91 | SHC1 | 27.95 | MAPK14 | 2595.51 | CCND1 | 0.55 | FGF2 | 50.07 |
| FGF2 | 6.08E+20 | RAC1 | 91 | FGF2 | 0.13 | RAC1 | 13.85 | TRIM37 | 27.94 | BDNF | 2517.18 | FGF2 | 0.55 | MAPK14 | 49.67 |
| MAPK14 | 5.63E+20 | IGF1R | 88 | MAPK14 | 0.12 | IGF1R | 13.78 | PIK3R1 | 27.61 | PIK3R1 | 2473.35 | IGF1R | 0.54 | RAC1 | 47.68 |
| KDR | 5.56E+20 | BDNF | 88 | KDR | 0.12 | BDNF | 13.78 | CCND1 | 27.49 | CCND1 | 2427.10 | MAP2K1 | 0.54 | BDNF | 47.07 |
| BDNF | 5.29E+20 | FGF2 | 87 | BDNF | 0.12 | FGF2 | 13.75 | UBE2W | 27.49 | IGF1R | 2356.76 | PRKCA | 0.54 | KDR | 44.41 |
| MAP2K1 | 5.19E+20 | KDR | 87 | MAP2K1 | 0.12 | KDR | 13.75 | UBE2G1 | 27.39 | IGF1 | 2353.36 | KDR | 0.54 | IGF1R | 43.30 |
| PTPN11 | 5.18E+20 | MAP2K1 | 82 | PTPN11 | 0.12 | MAP2K1 | 13.623 | CUL5 | 27.37 | SOCS1 | 2345.63 | RAC1 | 0.54 | MAP2K1 | 42.79 |
| SHC1 | 5.15E+20 | PRKCA | 81 | SHC1 | 0.12 | PRKCA | 13.60 | RHOA | 27.13 | PTPN11 | 2292.86 | BDNF | 0.54 | PTPN11 | 41.90 |
BC = betweenness centrality, CC = closeness centrality, DC = degree centrality, EC = eigenvector centrality, IC = information centrality, LAC = local average connectivity, NC = network centrality, PPI = Protein-protein interaction, SC = subgragh centrality.