Table 2.
Correlation of lumbar BMD levels and clinical variables by simple regression or multivariable linear regression analyses among the 80 hemodialysis patients.
| Variables | Lumbar BMD (g/cm2) | ||||
|---|---|---|---|---|---|
| Simple regression | Multivariable regression | ||||
| r | P | Beta | Adjusted R2 change | P | |
| Female | −0.430 | <0.001∗ | −0.353 | 0.134 | <0.001∗ |
| Diabetes mellitus | 0.164 | 0.146 | — | — | — |
| Hypertension | 0.162 | 0.152 | — | — | — |
| Age (years) | −0.268 | 0.016∗ | — | — | — |
| Log-HD duration (months) | −0.054 | 0.631 | — | — | — |
| Body mass index (kg/m2) | 0.332 | 0.003∗ | — | — | — |
| Systolic blood pressure (mmHg) | 0.208 | 0.064 | — | — | — |
| Diastolic blood pressure (mmHg) | 0.200 | 0.075 | — | — | — |
| Log-albumin (mg/dL) | 0.022 | 0,848 | — | — | — |
| Blood urea nitrogen (mg/dL) | 0.035 | 0.757 | — | — | — |
| Creatinine (mg/dL) | 0.297 | 0.007∗ | — | — | — |
| Alkaline phosphatase (U/L) | −0.294 | 0.008∗ | −0.176 | 0.022 | 0.049∗ |
| Total calcium (mg/dL) | −0.022 | 0.849 | — | — | — |
| Phosphorus (mg/dL) | 0.149 | 0.188 | — | — | — |
| Intact parathyroid hormone (pg/mL) | −0.137 | 0.244 | — | — | — |
| Log-irisin (ng/mL) | 0.517 | <0.001∗ | 0.450 | 0.258 | <0.001∗ |
| Urea reduction rate | −0.271 | 0.015∗ | — | — | — |
| Kt/V (Gotch) | −0.268 | 0.016∗ | — | — | — |
Data of HD duration, albumin, and irisin showed skewed distribution and therefore were log-transformed before analysis. Analysis of data was done using the univariate linear regression analyses or multivariate stepwise linear regression analysis (adapted factors were female, age, body mass index, creatinine, alkaline phosphatase, urea reduction rate, Kt/V, and log-irisin). HD, hemodialysis; Kt/V, fractional clearance index for urea. ∗P < 0.05 was considered statistically significant.