Fig. 4. Notch1 inhibition decreases islet mass and increases the numbers of small islets compared to large islets. (A) H&E staining and immunohistochemistry (IHC) of pancreatic section. (B) Islet diameter of 8-week-old male Notch1 antisense transgenic (NAS) and control mice. (C) Islet area of 8-week-old male NAS and control mice. (D) Islet number/4 mm2 of 8-week-old male NAS and control mice. (E) Islet number/4 mm2 according to the diameter (<250 µm vs. ≥250 µm). All data are represented as the mean±standard deviation. aP<0.05, bP<0.01, and cP<0.001 compared to the control mice (control, n=6; NAS, n=6).
