Fig. 6. Notch1 inhibition decreases insulin secretion in islet of 8-week-old male Notch1 antisense transgenic (NAS) compared to control mice. (A) Insulin secretion induced by glucose stimulation from 3.3 to 16.7 mmol/L. (B) Insulin release from perifused pancreas of control and NAS mice. All data are represented as the mean±standard deviation. ^aP<0.001 compared to the control mice (control, n=4; NAS, n=4).