Fig. 7. Neurogenin3 (Ngn3), neurogenic differentiation (NeuroD), and MAF bZIP transcription factor A (Maf-A) are increased in 8-week-old male Notch1 antisense transgenic (NAS) mice compared to control mice. Real-time polymerase chain reaction was performed on the transcription factors including Ngn3, NeuroD, Maf-A, pancreatic and duodenal homeobox 1 (Pdx1), and insulin 1 (Ins1). Total mRNA was isolated from mice islet. All data represented as mean±standard deviation. ^aP<0.05 compared with control mice (control, n=3; NAS, n=4).