Fig. 2.

Alignment of human and canine HS6ST2 genes. The alignment was created using Clustal Omega. The human sequence accession 10 is ENSP00000429473/1·645 and the canine sequence accession 10 is ENSCAFP00000038323/1/646. The putative transmembrane domain is highlighted in yellow; the two P-loop containing NTP hydrolase domains are highlighted in green and the region removed by alternate splicing that produces the short form is highlighted in pink (information derived from Habuchi et al. [42] and Ensembl). Asterisks indicate positions with a conserved amino acid; colons indicate conservation of amino acids with highly similar properties; periods indicate conservation of amino acids with weakly similar properties