Figure 6.

Amino acid sequence of human IFNα subtypes. IFNα subtypes are shown in order of arrangement on chromosome 9 with evolutionarily conserved and variant subtypes highlighted in blue and pink respectively. Secondary structure and IFNAR1/2 contact residues, labeled 1 and 2 respectively, are shown in the gray and blue highlighted text. Amino acids are shown with IFNα1 as the comparator, showing those that are unique to IFNα1 and otherwise identical among all the IFNα^−1/13 subtypes, or otherwise varies among the other IFNα^1/13 subtypes. * and † indicate cysteine disulfide bonds. Figure modified from (80).