Table 1.
Reported expression patterns of human IFN-I.
| Cell type | Stimulus | Conserved cluster | Variant cluster | CC | Reference | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| β | α1 | α8 | α2 | α6 | α5 | α14 | α17 | α16 | α10 | α7 | α4 | α21 | |||
| PBMC | poly I:C | X | X | X | X | X | (49) | ||||||||
| CpG B-D class | X | X | X | X | X | X | X | X | X | (53) | |||||
| Imiquimod | X | X | X | X | (53) | ||||||||||
| Sendai Virus a | nd | X | X | X | X | X | X | (19) | |||||||
| Hepatitis C virus | X | X | (54) | ||||||||||||
| Mo | poly I:C | X | X | X | (49) | ||||||||||
| MDM | poly I:C | X | X | X | (49) | ||||||||||
| CpG D class | X | X | X | ||||||||||||
| M. tuberculosis | X | X | (50) | ||||||||||||
| MDDC | poly I:C | X | X | (49) | |||||||||||
| RSV | X | X | X | X | X | X | (55) | ||||||||
| pDC | poly I:C, LPS | X | X | X | X | (49) | |||||||||
| Imiquimod | X | X | X | X | X | X | X | X | X | X | X | X | X | ||
| CpG A, C, D | X | X | X | X | X | X | X | X | X | X | X | X | X | ||
| CpG B class | nd | X | X | X | X | (48) | |||||||||
| IAV H1N1 | nd | X | X | X | X | X | X | X | X | X | X | X | X | (48) | |
| HIV | nd | X | X | X | X | X | X | X | X | X | X | X | X | (56) | |
| HIV | nd | X | X | X | X | X | (57) | ||||||||
| Calu3 b | IAV H5N1 IAV pH1N1 SARS-CoV MERS-CoV | X | X | (58) | |||||||||||
| BEAS2B | RSV | X | X | (51) | |||||||||||
| Lung explants | IAV H3N2 | nd | X | X | X | X | X | X | (59) | ||||||
| U937 c | Sendai Virus (low MOI) | X | X | X | X | x | x | x | x | x | x | x | x | x | (60) |
| Sendai Virus (high MOI) | X | X | X | X | X | X | X | X | |||||||
Expression patterns determined by mass spectrometry.
Expression patterns determined by RNAseq, which may be insensitive to detecting highly identical transcripts.
Lower case “x” refers to the IFNα subtypes that were not expressed after IFNAR2 blockade (see text).
PBMC, peripheral blood mononuclear cells; Mo, monocytes; MDM, monocyte derived macrophages; MDDC, monocyte derived dendritic cells; pDC, plasmacytoid dendritic cells; poly I:C, polyinosinic-polycytidylic acid; CpG, CpG oligodeoxynucleotides; HIV, human immunodeficiency virus; SARS-Cov, Severe adult respiratory syndrome coronavirus; MERS-CoV, Mideast respiratory syndrome coronavirus; MOI, multiplicity of infection. Blue and orange shading show evolutionarily conserved and variant IFNα subtypes, respectively.