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. 2020 May 12;37(1):35–49. doi: 10.1007/s10565-020-09525-5

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© The Author(s) 2020

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Fig. 5 — sf-RON promoted tumor growth by regulating β-catenin/SIX1 signaling in vivo. a Representative image of nude mice bearing tumors formed by sf-RON, sf-RON/β-catenin KD (Knockdown) and their control cells. b The average tumor volume of nude mice bearing tumors formed by sf-RON, sf-RON/β-catenin KD and their control cells. ** P < 0.01. c The average tumor weight of nude mice bearing tumors formed by sf-RON, sf-RON/β-catenin KD, and their control cells. d Representative image of PET-CT was used for the detection of glucose uptake in sf-RON, sf-RON/β-catenin KD xenografts, and their controls. e Average SUVmax values of nude mice bearing tumors. ** P < 0.01. f Immunohistochemical staining of β-catenin, SIX1, GLUT1, and LDHA in the sf-RON, sf-RON/β-catenin KD, and control tissues (magnification × 200)