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. 2020 Sep 3;49(2):689–702. doi: 10.1007/s10439-020-02598-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Perspective view, coronal view and sagittal view of the brain model reconstructed from the healthy control DMRI dataset, with the infusion catheter inserted in a WM region. The model simulates a constant infusion rate of $3 μ L / min$ . (b) Coronal section plane with a detail of the final mesh adopted for all the simulation after sensitivity analysis (Appendix 1).